Just Published in Chemistry - A European Journal
10/17/2024Tuning The Intracellular Distribution of [3+2+1] Iridium(III) Complexes In Bacterial And Mammalian Cells By iClick Reaction With Biomolecular Carriers Functionalized With Alkynone Groups
Authors: Victoria V. L. Müller, Dominik Moreth, Konrad Kowalski, Aleksandra Kowalczyk, Magdalena Gapińska, Roger Jan Kutta, Patrick Nuernberger, Ulrich Schatzschneider
Abstract: The colour and intracellular distribution of iridium(III) complexes is tuned by iClick conjugation of different biomolecular carriers”. The iClick (inorganic click) reaction enables a modular modification of iridium(III) complexes with ancillary triazolato ligands carrying biological targeting groups like biotin and cholic acid. The stability and non-toxicity of these compounds facilitates their use as biological imaging probes in bacterial and human cancer cells. Their intracellular localization can be tuned by proper peripheral functionalization of the complexes.
Link: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202401603
