Daniela Pemp

Pharmacist (University of Regensburg)

Tel.: +49 931 318 8696

Raum: 02.004

PhD Thesis

The topic of the PhD Thesis is the identification of factors influencing levels of estrogens in breast tissue and plasma of women and of female rats.

Part of the project Food constituents as molecular modulators of carcinogenesis

Reviewed scientific journal articles

Kleider C, Calderón G J, Pemp D, Esch HL, Lehmann L (2022). Validation of a GC- and LC-MS/MS based method for the quantification of 22 estrogens and its application to human plasma. Steroids. https://doi.org/10.1016/j.steroids.2022.109077. Epub 2022 July 02.

Wunder J, Pemp D, Cecil A, Mahdiani M, Hauptstein R, Schmalbach K, Geppert LN, Ickstadt K, Esch HL, Dandekar T, Lehmann L (2022). Influence of breast cancer risk factors on proliferation and DNA damage in human breast glandular tissues: role of intracellular estrogen levels, oxidative stress and estrogen biotransformation. Arch Toxicol. doi.org/10.1007/s00204-021-03198-7. Epub 2021 December 18.

Pemp D, Geppert LN, Wigmann C, Kleider C, Hauptstein R, Schmalbach K, Ickstadt K, Esch HL, Lehmann L (2020). Influence of breast cancer risk factors and intramammary biotransformation on estrogen homeostasis in the human breast. Arch Toxicol. doi.org/10.1007/s00204-020-02807-1. Epub 2020 June 22.

ter Mors B, Pemp D, Lehmann L, Lorson T, Meinel L (2020). Comparison of polysorbate 20 qualities. Pharm. Ind. 82, Nr. 8, 1064-1071.

Pemp D, Kleider C, Schmalbach K, Hauptstein R, Geppert LN, Köllmann C, Ickstadt K, Eckert P, Neshkova I, Jakubietz R, Esch HL, Lehmann L (2019). Qualitative and quantitative differences in estrogen biotransformation in human breast glandular and adipose tissues: implications for studies using mammary biospecimens. Arch Toxicol. doi.org/10.1007/s00204-019-02564-w. Epub 2019 September 05.

Pemp D, Esch HL, Hauptstein R, Möller FJ, Zierau O, Boslan MC, Geppert LN, Kleider C, Schlereth K, Vollmer G, Lehmann L (2019). Novel insight in estrogen homeostasis and bioactivity in the ACI rat model of estrogen-induced mammary gland carcinogenesis. Arch Toxicol., Volume 93 (7), 1979-1992 doi: 10.1007/s00204-019-02483-w . Epub 2019 May 25.

Möller FJ, Pemp D, Soukup ST, Wende K, Zhang X, Zierau O, Muders MH, Bosland MC, Kulling SE, Lehmann L, Vollmer G. Soy isoflavone exposure through all life stages accelerates 17β-estradiol-induced mammary tumor onset and growth, yet reduces tumor burden, in ACI rats. Archives of toxicology. 2016 1-10. doi:10. 1007/ s00204-016-1674-2
www.ncbi.nlm.nih.gov/pubmed/26861028

Huang G, Pemp D, Stadtmüller P, Nimczick M, Heilmann J, Decker M. Design, synthesis and in vitro evaluation of novel uni- and bivalent ligands for the cannabinoid receptor type 1 with variation of spacer length and structure. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4209-14. doi: 10.1016/j.bmcl.2014.07.038.
www.ncbi.nlm.nih.gov/pubmed/25096297

Nimczick M, Pemp D, Darras FH, Chen X, Heilmann J, Decker M. Synthesis and biological evaluation of bivalent cannabinoid receptor ligands based on hCB2R selective benzimidazoles reveal unexpected intrinsic properties. Bioorg Med Chem. 2014 Aug 1;22(15):3938-46. doi: 10.1016/j.bmc.2014.06.008.
www.ncbi.nlm.nih.gov/pubmed/24984935

Congress contributions

Veh E, Schulze F, Leonhardt D, Kleider C, Lehmann L (2023). The human endometrial adenocarcinoma Ishikawa cell line as promising test system for SULT-mediated activation of genotoxins. Posterbeitrag. 8^th German Pharm-Tox Summit 2023, Ulm, Deutschland.

Pemp D, Wunder J, Brendel K, Bernhard‐Brendel M, Lehmann L (2022) Entwicklung einer Smartphone‐App zur personalisierten Auswahl geeigneter Lebensmittel bei Unverträglichkeiten, Allergien und Arzneimitteleinnahme: Möglichkeiten und Grenzen. Lebensmittelchemie 76(S2):S2-038. https://doi.org/10.1002/lemi.202259015

Raps M, Kranz J, Kleider C, Pemp D und Lehmann L (2022). Analysis of estrogens, androgens and metabolites thereof in human plasma by GC-and LC-MS/MS combining direct detection and specific hydrolysis of glucuronide conjugates. Posterbeitrag. EUREKA! Symposium 2022, Würzburg.

Raps M, Kleider C, Pemp D und Lehmann L (2021). Proof of concept for the specific analysis of glucuronide conjugates of estrogens and their metabolites in human plasma after hydrolysis. Posterbeitrag. EUREKA! Symposium 2021, online.

Markert L, Kleider C, Merz B, Pemp C, Bub A, Kulling S, Lehmann L (2021). Association of breast cancer associated nutritional factors on plasma levels of 17ß-Estradiol. Posterbeitrag. EUREKA! Symposium 2021, online.

Jaud T, Pemp D, Mahdiani M und Lehmann L (2020). Lack of significant influence of endogenous and exogenous estrogens on Δ9-16-desaturase index in human breast adipose tissue. Beitrag im Abstractband. 57. Wissenschaftlicher Kongress der DGE 2020.

Jaud T, Pemp D, Mahdiani M und Lehmann L (2020). Lack of significant influence of endogenous and exogenous estrogens on Δ9-16-desaturase index in human breast adipose tissue. Posterbeitrag. EUREKA! Symposium 2020, Würzburg.

Jaud T, Pemp D und Lehmann L (2020). Influence of dietary fatty acid biomarkers on desaturase and elongase indices in human breast adipose tissue. The Toxicologist. Posterbeitrag. 59th Annual Meeting of the Society of Toxicology, March 2012, online.

Jaud T, Huber A, Pemp D und Lehmann L (2020). Bestimmung des Fettsäureprofils unter Berücksichtigung von Biomarkern für die Ernährungsweise im Humanfettgewebe. Posterbeitrag. 71. Arbeitstagung des Regionalverbandes Bayern der Lebensmittelchemischen Gesellschaft 2020, Würzburg.

Albrecht T, Häfner L, Müller S, Pemp D, Vollmer G und Lehmann L (2019). Effect of 17β-hydroxysteroid dehydrogenase inhibition on estrogen levels in bone in an animal rat model. Vortrag. 21st Annual YARE Meeting 2019, Essen.

Albrecht T, Häfner L, Müller S, Pemp D, Vollmer G und Lehmann L (2019). Möglicher Einfluss von Lebensmittelinhaltsstoffen auf die Knochendichte durch Modulierung der Hydroxysteroid-Dehydrogenase 17B-Aktivität. Posterbeitrag. 48. Deutscher Lebensmittelchemikertag 2019, Dresden.

Albrecht T, Kleider C, Jaud T, Pemp D, Esch HL und Lehmann L (2018). Entwicklung einer Quantifizierungsstrategie für Estrogen-Fettsäureester in humanem Fettgewebe: Synthesewege und Darstellung von Standards. Posterbeitrag. 47. Deutscher Lebensmittelchemikertag 2018, Berlin.

Hauptstein R, Pemp D, Spielmann B, Kleider C, Weck S, Schmalbach K, Soukup ST, Geppert LN, Köllmann C, Kulling S, Dandekar T, Eckert P, Neshkova I, Jakubietz R, Esch HL, Lehmann L (2017). Association of genistein with 17β-estradiol and estrogen receptor activation but not with metabolic fluxes to estrogen-DNA adducts in the human breast. The Toxicologist. Poster presentation. 56th Annual Meeting of the Society of Toxicology, March 2017, Baltimore, MD, USA.

Pemp D, Kleider C, Möller FJ, Schlereth KS, Neshkova I, Vollmer G, Esch HL, Lehmann L (2016). Comparison of Quantitative Estrogen Profiles in Plasmas and Mammary Glands of Women with Those in a Rat Model of Estrogen-induced Tumorigenesis. The Toxicologist. Vortrag. 55th Annual Meeting of the Society of Toxicology, March 2016, New Orleans, LA, USA.

Schmalbach K, Alexander Cecil A, Hauptstein R, Soukup ST, Pemp D, Kleider C, Geppert LN, Köllmann C, Eckert P, Neshkova I, Dandekar T, Kulling S, Esch HL, Lehmann L (2016). Metabolic network of estrogen metabolism in human mammary gland: Validation and influence of soy isoflavones. The Toxicologist. Posterbeitrag. 55th Annual Meeting of the Society of Toxicology, March 2016, New Orleans, LA, USA.

Pemp D, Hauptstein R, Möller FJ, Kleider C, Schlereth KS, Bosland MC, Esch HL, Vollmer G, Lehmann L (2016). E2 metabolite profiles and related transcripts during the tumorigenic process in the mammary gland of female August Copenhagen Irish rats: impact of isoflavones. Naunyn-Schmiedeberg's Arch. Pharmacology. Posterbeitrag. 82nd Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology, March 2016, Berlin.

Hauptstein R, Pemp D, Möller FJ, Esch HL, Vollmer G, Lehmann L (2016). Impact of different isoflavone exposure scenarios on estrogen levels and estrogen receptor activation in mammary glands of August Copenhagen Irish rats Naunyn-Schmiedeberg's Arch. Pharmacology. Posterbeitrag. 82nd Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology, March 2016, Berlin.

Kleider C, Pemp D, Hauptstein R, Schmalbach K, Soukup ST, Geppert L, Köllmann C, Brückner L, Eckert P, Neshkova I, Ickstadt K, Kulling S, Esch HL, Lehmann L (2016). Correlations of tissue levels of soy isoflavones with 17beta-estradiol/estrone ratio and transcript levels of 17beta-hydroxysteroid dehydrogenase in human mammoplasty specimen. Naunyn-Schmiedeberg's Arch. Pharmacology. Posterbeitrag. 82nd Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology, March 2016, Berlin.

Mahdiani M, Pemp D, Eckert P, Neshkova I, Esch HL, Lehmann L (2016). Quantitative profiles of autoxidation products of cholesterol in human mammoplasty specimen. Naunyn-Schmiedeberg's Arch. Pharmacology. Posterbeitrag. 82nd Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology, March 2016, Berlin.

Kleider C, Schmalbach K, Pemp D, Hauptstein R, Gepper LN, Köllmann C, Neshkova I, Ickstadt K, Esch HL, Lehmann L (2015). Qualitative and quantitative differences between levels of estrogens and their conjugates as well as transcripts in breast adipose and glandular tissue derived from mammoplasty specimens. Posterbeitrag 3rd International Congress on Steroid Research, November 2015, Chicago, IL, USA.

Möller FJ, Pemp D, Soukup ST, Wende K, Zierau O, Moders MH, Bosland MC, Kulling SE, Lehmann L, Vollmer G (2015). Developmental windows of disease and disease prevention – Lessons from a study on soy isoflavones and experimental breast cancer. Vortrag 3rd International Congress on Steroid Research, November 2015, Chicago, IL, USA.

Schmalbach K, Cecil A, Hauptstein R, Soukup S, Pemp D, Kleider C, Geppert LN, Köllmann C, Eckert P, Neshkova I, Dandekar T, Kulling S, Esch HL, Lehmann L (2015). Influence of soy isoflavones on metabolic flux of estrogen DNA adducts in female mammary gland. Posterbeitrag. Internationale Sommerschule: Pflanzliche Polyphenole als Leitstrukturen für Arzneimittel, September 2015, Dresden.

Schmalbach K, Cecil A, Hauptstein R, Soukup S, Pemp D, Kleider C, Geppert LN, Köllmann C, Eckert P, Neshkova I, Dandekar T, Kulling S, Esch HL, Lehmann L (2015). Untersuchungen zum Einfluss von Sojaisoflavonen auf den metabolischen Fluss von Estrogen-DNA-Addukten in der gesunden weiblichen Brustdrüse. Posterbeitrag. 44. Deutscher Lebensmittelchemikertag, September 2015, Karlsruhe.

Kleider C, Pemp D, Schmalbach K, Soukup S, Hauptstein R, Eckert P, Neshkova I, Kulling S, Esch HL, Lehmann L (2015). Korrelation der Gewebespiegel von Sojaisoflavonen mit denen von Estrogenen und deren metabolisierenden Enzymen in Brustdrüsen von gesunden Frauen. Posterbeitrag. 44. Deutsche Lebensmittelchemikertag, September 2015, Karlsruhe.