Dr. Harald Esch

Dr. rer. nat. Food Chemstry (TH Karlsruhe)

Phone: +49 931 318 6964

Room: 02.030

Reviewed scientific journal articles

Kleider C, Calderón G J, Pemp D, Esch HL, Lehmann L (2022). Validation of a GC- and LC-MS/MS based method for the quantification of 22 estrogens and its application to human plasma. Steroids. doi.org/10.1016/j.steroids.2022.109077. Epub 2022 July 02.

Wunder J, Pemp D, Cecil A, Mahdiani M, Hauptstein R, Schmalbach K, Geppert LN, Ickstadt K, Esch HL, Dandekar T, Lehmann L (2022). Influence of breast cancer risk factors on proliferation and DNA damage in human breast glandular tissues: role of intracellular estrogen levels, oxidative stress and estrogen biotransformation. Arch Toxicol. doi.org/10.1007/s00204-021-03198-7. Epub 2021 December 18.

Pemp D, Geppert LN, Wigmann C, Kleider C, Hauptstein R, Schmalbach K, Ickstadt K, Esch HL, Lehmann L (2020). Influence of breast cancer risk factors and intramammary biotransformation on estrogen homeostasis in the human breast. Arch Toxicol. doi.org/10.1007/s00204-020-02807-1. Epub 2020 June 22.

Pemp D, Kleider C, Schmalbach K, Hauptstein R, Geppert LN, Köllmann C, Ickstadt K, Eckert P, Neshkova I, Jakubietz R, Esch HL, Lehmann L (2019). Qualitative and quantitative differences in estrogen biotransformation in human breast glandular and adipose tissues: implications for studies using mammary biospecimens. Arch Toxicol. doi.org/10.1007/s00204-019-02564-w. Epub 2019 September 05.

Pemp D, Esch HL, Hauptstein R, Möller FJ, Zierau O, Boslan MC, Geppert LN, Kleider C, Schlereth K, Vollmer G, Lehmann L (2019). Novel insight in estrogen homeostasis and bioactivity in the ACI rat model of estrogen-induced mammary gland carcinogenesis. Arch Toxicol., Volume 93 (7): 1979-92. doi: 10.1007/s00204-019-02483-w . Epub 2019 May 25.

Hiltensperger G, Hecht N, Kaiser M, Rybak JC, Hoerst A, Dannenbauer N, Müller-Buschbaum K, Bruhn H, Esch H, Lehmann L, Meinel L, Holzgrabe U. Quinolone Amides as Antitrypanosomal Lead Compounds with In Vivo Activity. Antimicrob Agents Chemother. (2016 Jul 22); 60(8):4442-52. doi: 10.1128/AAC.01757-15. Print 2016 Aug.

Scheffler A, Albrecht A, Esch H, Lehmann L. Data in support of the mutagenic potential of the isoflavone irilone in cultured V79 cells Toxicology Letters 234 (2015), pp. 81-91. doi:10.1016/j.dib.2015.07.010

Scheffler A, Albrecht A, Esch H, Lehmann L. Mutagenic potential of the isoflavone irilone in cultured V79 cells. Toxicology Letters 234 (2015), pp. 81-91. 10.1016/j.toxlet.2015.02.013

Pfenning C, Esch HL, Fliege R, Lehmann L. The mycotoxin patulin reacts with DNA bases with and without previous conjugation to GSH: implication for related α,β-unsaturated carbonyl compounds? Arch Toxicol. 2014 Dec 24

Lutter S, Schmalbach K, Esch HL, Lehmann L. The isoflavone irilone contributes to the estrogenic potential of dietary supplements containing red clover. Arch Toxicol. 88(2) (2013), pp. 309-21, DOI: 10.1007/s00204-013-1114-5. Print 2014 Feb.

Lödige M, Lewis MD, Paulsen ES, Esch HL, Pradel G, Lehmann L, Brun R, Bringmann G, Mueller AK. A primaquine-chloroquine hybrid with dual activity against Plasmodium liver and blood stages. Int J Med Microbiol. 2013 Aug 5. doi:pii: S1438-4221(13)00101-X.10.1016/j.ijmm.2013.07.005.

Lauby-Secretan B, Loomis D, Grosse Y, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Baan R, Mattock H, Straif K; International Agency for Research on Cancer Monograph Working Group IARC, Lyon, France. Collaborators (25):
Cogliano VJ, Aronson K, Tryphonas H, Guo YL, Machala M, Bonefeld-Jørgensen EC, Vorkamp K, Cravedi JP, Le Bizec B, Narbonne JF, Esch H, Cocco P, Merletti F, Vermeulen R, Agudo A, Johansson N, Fiedler H, Hopf N, Glauert HP, Herbert RA, James MO, Ludewig G, Robertson L, Ruder A, Walker N. Carcinogenicity of polychlorinated biphenyls and polybrominated biphenyls. Lancet Oncol. 2013 Apr;14(4):287-8. doi: 10.1016/S1470-2045(13)70104-9. Epub 2013 Mar 15.

Jacobus JA, Wang B, Maddox C, Esch H, Lehmann L, Robertson LW, Wang K, Kirby P, Ludewig G (2010). 3-Methylcholanthrene (3-MC) and 4-Chlorobiphenyl (PCB3) genotoxicity is gender-related in Fischer 344 transgenic rats. Environ. Int. 36, 970-979.

Garcia C, Ball N, Cagen S, Carrillo JC, Certa H, Eigler D, Esch H, Graham C, Haux C, Kreiling R, Mehling A (2010). Comparative testing for the identification of skin-sensitizing potentials of nonionic sugar lipid surfactants. Regul. Toxicol. Pharmacol. 58, 301-307.

Basketter D, Ball N, Cagen S, Carrillo JC, Certa H, Eigler D, Garcia C, Esch H, Graham C, Haux C, Kreiling R, Mehling A (2009). Application of a weight of evidence approach to assessing discordant sensitisation datasets: implications for REACH. Regul. Toxicol. Pharmacol. 55, 90-96.

Ludewig G, Lehmann L, Esch H, Robertson LW (2008). Metabolic Activation of PCBs to Carcinogens in Vivo - A Review. Environ. Toxicol. Pharmacol. 25, 241-246.

Lehmann L, Esch HL, Kirby AP, Robertson LW, Ludewig G (2007). 4-monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats. Carcinogenesis 28, 471-478.

Lehmann L, Esch HL, Wagner J, Rohnstock L, Metzler M (2005). Estrogenic and genotoxic potential of equol and two hydroxylated metabolites of Daidzein in cultured human Ishikawa cells. Toxicol. Lett. 158, 72-86.

Book contributions

Esch HL, Kleider C, Scheffler A, Lehmann L (2016). Isoflavones: Toxicological aspects and efficacy. In: Nutraceuticals: Efficacy, Safety and Toxicity edited by R.C. Gupta. Elsevier, pp. 467-489.

Ludewig G, Esch H, Robertson LW (2006). Polyhalogenierte Bi- und Terphenyle. In: Handbuch der Lebensmitteltoxikologie. Dunkelberg H, Gebel T, Hartwig A (Hrsg.), Wiley-VCH, Weinheim, 1031-1070.

Invited journal articles

Lehmann L, Esch H (2010). Gesundheitsbezogene Angaben zu Lebensmitteln sowie Gehalte, Verfügbarkeit und Wirksamkeit von Polyphenolen. Nachrichten aus der Chemie 58, 339-344.

Congress contributions

Calderón G J, Kleider C, Esch HL and Lehmann L (2018). UHPLC-MS/MS-based analysis of Methoxy-Estrone/Estradiol-glucuronides in human plasma. Posterbeitrag. 20th Annual YARE Meeting 2018, Herrsching am Ammersee.

Albrecht T, Kleider C, Jaud T, Pemp D, Esch HL und Lehmann L (2018). Entwicklung einer Quantifizierungsstrategie für Estrogen-Fettsäureester in humanem Fettgewebe: Synthesewege und Darstellung von Standards. Posterbeitrag. 47. Deutscher Lebensmittelchemikertag 2018, Berlin.

Calderón G J, Kleider C, Wianz S, Esch HL and Lehmann L (2017). Biosynthesis, identification and quantification of MeO-estrogen glucuronides: key E1/E2 metabolites in breast cancer etiology. Posterbeitrag. 46. Deutscher Lebensmittelchemikertag 2017, Würzburg.

Hauptstein R, Pemp D, Spielmann B, Kleider C, Weck S, Schmalbach K, Soukup ST, Geppert LN, Köllmann C, Kulling S, Dandekar T, Eckert P, Neshkova I, Jakubietz R, Esch HL, Lehmann L (2017). Association of genistein with 17β-estradiol and estrogen receptor activation but not with metabolic fluxes to estrogen-DNA adducts in the human breast. The Toxicologist. Poster presentation. 56th Annual Meeting of the Society of Toxicology, March 2017, Baltimore, MD, USA.

Spielmann B, Schmalbach K, Cecil A, Hauptstein R, Pemp D, Kleider C, Geppert L, Köllmann C, Eckert P, Neshkova I, Dandekar T, Esch H, Lehmann L (2017). Identification of variables affecting metabolic estrogen-DNA adduct fluxes in human glandular breast tissues. Poster presentation. 2nd German Pharm-Tox Summit – 83rd Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT), March 2017, Heidelberg, Deutschland.

Pemp D, Spielmann D, Hauptstein R, Kleider C, Weck S, Schmalbach K, Soukup ST, Geppert LN, Köllmann C, Kulling S, Dandekar T, Ickstadt K, Eckert P, Neshkova I, Jakubietz R, Esch HL, Lehmann L (2016). Association of genistein with 17β-estradiol and estrogen receptor activation but not with metabolic fluxes to estrogen-DNA adducts in the human breast. Oral presentation. Symposium "DNA damage response, genetic instability and cancer" des ITOX Mainz und der AK Karzinogenese der GT, November 2016, Mainz, Deutschland.

Kleider C, Esch HL, Lehmann L (2016). Reactivity against DNA bases despite previous conjugation to glutathione - A new mechanism of toxicity of alpha,beta(,gamma,delta)-unsaturated carbonyls? Posterbeitrag. Symposium "DNA damage response, genetic instability and cancer" des ITOX Mainz und der AK Karzinogenese der GT, November 2016, Mainz.

Pemp D, Spielmann B, Hauptstein R, Kleider C, Weck S, Schmalbach K, Soukup ST, Geppert LN, Köllmann C, Kulling S, Dandekar T, Ickstadt K, Eckert P, NeshkovaI, Jakubietz R, Esch HL, Lehmann L (2016). The isoflavone genistein is positively associated with tissue levels of 17β-estradiol but does not affect metabolic fluxes to estrogen-DNA adducts and even reduces estrogen receptor activation in human mammary gland. Poster presentation. Meeting der Gesellschaft für Umwelt-Mutationsforschung e.V. (GUM), Oktober 2016, Neuherberg.

Kleider C, Esch HL, Lehmann L (2016). Reactivity against DNA bases despite previous conjugation to glutathione - A new mechanism of toxicity of alpha,beta(,gamma,delta)-unsaturated carbonyls? Vortrag. GUM Meeting der Gesellschaft für Umwelt-Mutationsforschung e.V., Oktober 2016, Neuherberg.

Pemp D, Kleider C, Möller FJ, Schlereth KS, Neshkova I, Vollmer G, Esch HL, Lehmann L (2016). Comparison of Quantitative Estrogen Profiles in Plasmas and Mammary Glands of Women with Those in a Rat Model of Estrogen-induced Tumorigenesis. The Toxicologist. Vortrag. 55th Annual Meeting of the Society of Toxicology, March 2016, New Orleans, LA, USA.

Schmalbach K, Alexander Cecil A, Hauptstein R, Soukup ST, Pemp D, Kleider C, Geppert LN, Köllmann C, Eckert P, Neshkova I, Dandekar T, Kulling S, Esch HL, Lehmann L (2016). Metabolic network of estrogen metabolism in human mammary gland: Validation and influence of soy isoflavones. The Toxicologist. Posterbeitrag. 55th Annual Meeting of the Society of Toxicology, March 2016, New Orleans, LA, USA.

Pemp D, Hauptstein R, Möller FJ, Kleider C, Schlereth KS, Bosland MC, Esch HL, Vollmer G, Lehmann L (2016). E2 metabolite profiles and related transcripts during the tumorigenic process in the mammary gland of female August Copenhagen Irish rats: impact of isoflavones. Naunyn-Schmiedeberg's Arch. Pharmacology, 389. Posterbeitrag. 82nd Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology, March 2016, Berlin.

Mahdiani M, Pemp D, Eckert P, Neshkova I, Esch HL, Lehmann L (2016). Quantitative profiles of autoxidation products of cholesterol in human mammoplasty specimen. Naunyn-Schmiedeberg's Arch. Pharmacology. Posterbeitrag. 82nd Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology, March 2016, Berlin.

Kleider C, Pemp D, Hauptstein R, Schmalbach K, Soukup ST, Geppert L, Köllmann C, Brückner L, Eckert P, Neshkova I, Ickstadt K, Kulling S, Esch HL, Lehmann L (2016). Correlations of tissue levels of soy isoflavones with 17beta-estradiol/estrone ratio and transcript levels of 17beta-hydroxysteroid dehydrogenase in human mammoplasty specimen. Naunyn-Schmiedeberg's Arch. Pharmacology, 389. Posterbeitrag. 82nd Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology, March 2016, Berlin.

Hauptstein R, Pemp D, Möller FJ, Esch HL, Vollmer G, Lehmann L (2016). Impact of different isoflavone exposure scenarios on estrogen levels and estrogen receptor activation in mammary glands of August Copenhagen Irish rats Naunyn-Schmiedeberg's Arch. Pharmacology. Posterbeitrag. 82nd Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology, March 2016, Berlin.

Möller FJ, Pemp D, Soukup ST, Wende K, Zierau O, Moders MH, Bosland MC, Kulling SE, Lehmann L, Vollmer G (2015). Developmental windows of disease and disease prevention – Lessons from a study on soy isoflavones and experimental breast cancer. Vortrag 3rd International Congress on Steroid Research, November 2015, Chicago, IL, USA.

Kleider C, Schmalbach K, Pemp D, Hauptstein R, Geppert LN, Köllmann C, Neshkova I, Ickstadt K, Esch HL, Lehmann L (2015). Qualitative and quantitative differences between levels of estrogens and their conjugates as well as transcripts in breast adipose and glandular tissue derived from mammoplasty specimens. Posterbeitrag. 3rd Congress on Steroid Research, 15.-18.11.2015, Chicago, USA.

Schmalbach K, Cecil A, Hauptstein R, Soukup S, Pemp D, Kleider C, Geppert LN, Köllmann C, Eckert P, Neshkova I, Dandekar T, Kulling S, Esch HL, Lehmann L (2015). Influence of soy isoflavones on metabolic flux of estrogen DNA adducts in female mammary gland. Posterbeitrag. Internationale Sommerschule: Pflanzliche Polyphenole als Leitstrukturen für Arzneimittel, September 2015, Dresden.

Schmalbach K, Cecil A, Hauptstein R, Soukup S, Pemp D, Kleider C, Geppert LN, Köllmann C, Eckert P, Neshkova I, Dandekar T, Kulling S, Esch HL, Lehmann L (2015). Untersuchungen zum Einfluss von Sojaisoflavonen auf den metabolischen Fluss von Estrogen-DNA-Addukten in der gesunden weiblichen Brustdrüse. Posterbeitrag. 44. Deutscher Lebensmittelchemikertag, September 2015, Karlsruhe.

Kleider C, Pemp D, Schmalbach K, Soukup S, Hauptstein R, Eckert P, Neshkova I, Kulling S, Esch HL, Lehmann L (2015). Korrelation der Gewebespiegel von Sojaisoflavonen mit denen von Estrogenen und deren metabolisierenden Enzymen in Brustdrüsen von gesunden Frauen. Lebensmittelchemie. Posterbeitrag. 44. Deutscher Lebensmittelchemikertag, 14.-16.09.2015, Karlsruhe.

Pfenning C, Esch H L, Lehmann L (2014). Formation of depurinating adducts of the food contaminant patulin with and without involvement of glutathione. Naunyn-Schmiedeberg's Arch. Pharmacol., 387. Posterbeitrag. 80. Jahrestagung der Deutschen Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie (DGPT), 01.–03.04.2014, Hannover.

Pfenning C, Esch H L, Lehmann L (2014). Bildung von Basenaddukten durch Reaktion des Mykotoxins Patulin mit DNA-Basen mit und ohne Beteiligung von Glutathion. Vortrag. 65. Arbeitstagung des Regionalverbandes Bayern der Lebensmittelchemischen Gesellschaft, 24. Februar 2014, Würzburg.

Lehmann L, Pfenning C, Esch H L (2012). Activation of the mycotoxin patulin by reaction with glutathione: A putative mechanism of adduct formation with adenine. The Toxicologist, 126, S138. Posterbeitrag. 51. Jahrestagung der Society of Toxicology (SOT), 11. - 15.03.2012, San Francisco, California, USA.

Esch HL, Pfeiffer E, Metzler M, Lehmann L (2010). Formation of mixed adducts with glutathion and adenine: a possible contribution to the mutagenicity of the mycotoxin patulin. The Toxicologist, 114, 310. Diskussionsbeitrag. 49. Jahrestagung der Society of Toxicology, 07.-11.03.2010, Salt Lake City, Utah, USA.

Carrillo J-C, Stuart C, Haux C, Ball N, Certa H, Eigler D, Garcia C, Graham C, Kreiling R, Mehling A, Esch H (2009). Surfactants: Inconsistent results between the LLNA and guinea pig sensitization tests. Toxicol. Lett. 189, S269. Posterbeitrag. 46. Kongress der European Societies of Toxicology, 13-16.09.2009, Dresden, Germany.

Garcia C, Ball N, Cagen S, Carrillo J-C, Certa H, Eigler D, Esch H, Graham C, Haux C, Kreiling R, Mehling A (2009). Comparison of LLNA and GPMT results for the identification of skin sensitizing potentials of the category of non-ionic sugarlipid surfactants. Toxicol. Lett. 189, S268. Posterbeitrag. 46. Kongress der European Societies of Toxicology, 13-16.09.2009, Dresden, Germany.

Basketter D, Ball N, Cagen S, Carrillo J-C, Certa H, Eigler D, Esch H, Garcia C, Graham C, Haux C, Kreiling R, Mehling A (2009). Analysing discordant local lymph node assay datasets: Implications for REACH. Toxicol. Lett. 189, S267. Posterbeitrag. 46. Kongress der European Societies of Toxicology, 13-16.09.2009, Dresden, Germany.

Jacobus J, Lehmann L, Esch HL, Robertson LW, Ludewig G (2007). Assessment of 4-chlorobiphenyl in vivo using the Big Blue rat model: mutagenicity, gene expression, and histology. The Toxicologist 86, 158. Posterbeitrag. 46. Jahrestagung Society of Toxicology, 25.-29.03.2007, Charlotte, North Carolina, USA.

Lehmann L, Flor S, Zettner M, Esch HL, Robertson LW, Ludewig G (2006). Mutagenicity of 4-monochlorobiphenyl and its metabolites in vitro and in vivo. Drug Metab. Rev. 38 (S3), 163. Posterbeitrag. 14th North American ISSX Meeting, 22. - 26.10.2006, Rio Grande, Puerto Rico.

Esch HL, Lehmann L, Robertson LW, Ludewig G (2006). 4-Monochlorobiphenyl is mutagenic in the liver of transgenic BigBlue® rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 372, 106. Posterbeitrag. 47. Frühjahrstagung der Deutschen Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie (DGPT), 04.-06.04.2006, Mainz, Deutschland.

Jacobus J, Lehmann L, Esch HL, Robertson LW, Ludewig G (2006). Detection of DNA base mutations in vivo after exposure to 4-chlorobiphenyl (PCB3) using the Big Blue rat model. Posterbeitrag. Superfund Basic Research Program Annual Meeting, 11.-12.12.2006, San Diego, California, USA. Best student poster award (Biomedical) an J. Jacobus.

Jacobus J, Lehmann L, Esch HL, Robertson LW, Ludewig G (2006). The transgenic Big Blue rat – A model system to analyze the in vivo mutagenicity of PCBs. Posterbeitrag. 4th PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs, 06.-10.09.2006, Zakopane, Polen.

Esch HL, Ludewig G (2005). PBDEs or PCBs with perfluorinated compounds: synergy in the induction of Se-glutathione peroxidase, cell cycle arrest and cytotoxicity in human HepG2 cells. Mutat. Res. 577S. Posterbeitrag. 9th International Conference on Environmental Mutagens/36th Annual Meeting of the Environmental Mutagen Society, 03.-08.09.2005 San Francisco, California, USA.

Esch HL, Robertson LW, Ludewig G (2005). Mixture effects of PCBs and PBDEs with other contaminants/drugs. The Toxicologist 84, 421. Posterbeitrag. 44. Jahrestagung der Society of Toxicology, 06.-10.03.2005, New Orleans, Louisiana, USA.

Pfeiffer E, Esch HL; Hoehle S, Solyom AM, Timmermann BN, Metzler M (2004). In vitro studies on the estrogenic activity and the metabolism of curcumin. Functional Food: Safety Aspects, 325-329. Posterbeitrag. Symposium der DFG Senatskommission zur Beurteilung der gesundheitlichen Unbedenklichkeit von Lebensmitteln, 05.-07.05.2002, Karlsruhe, Deutschland.

Lehmann L, Förster R, Esch HL, Metzler M (2004). Studies on the estrogenic and genotoxic potential of equol and two hydroxylated daidzein metabolites in cultured Ishikawa cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 369, R115. Posterbeitrag 45. Frühjahrstagung der Deutschen Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie (DGPT), 09.-11.03.2004, Mainz, Deutschland.

Esch HL, Pfeiffer E, Metzler M (2003). Estrogenic and antiestrogenic properties of bisphenol A and related bisphenols in Ishikawa cells. The Toxicologist 72, 134-135. Posterbeitrag. 42. Jahrestagung der Society of Toxicology, 09.-13.03.203, Salt Lake City, Utah, USA.

Lehmann L, Esch HL, Metzler M (2003). Transcription and activation of estrogen target genes: reliable quantification by competitive reverse transcription/polymerase chain reaction. Posterbeitrag. 4th Karlsruhe Nutrition Symposium, 08.-11.10.2003, Karlsruhe, Deutschland.

Pfeiffer E, Esch HL, Höhle S, Metzler M, Solyom AM, Timmermann BN (2002). Chemical stability of curcuminoids and their estrogenic activity in Ishikawa cells. The Toxicologist 66, LB 112. Posterbeitrag. 41. jahrestagung der Society of Toxicology, 09.-13.03.2002, USA.

Esch HL, Newill I, Pfeiffer E, Metzler M (2002). Estrogenic activity assessment of xenoestrogens based on the stimulation of alkaline phosphatase in Ishikawa cells. Naunyn-Schmiedeberg‘s Arch. Pharmacol. 365 (S1), R155. Posterbeitrag. 43. Frühjahrstagung der Deutschen Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie (DGPT), 12.-14.03.2002, Mainz, Deutschland.

Esch HL, Newill I, Pfeiffer E, Metzler M (2001). Estrogenic activity assessment of xenoestrogens based on the stimulation of alkaline phosphatase in Ishikawa cells. Posterbeitrag. 9. Gordon Research Conference on Hormonal Carcinogenesis, 08.-13.07.2001, Meriden, Maine, USA.