2023-2014
David Harris, Marcel Groß, Sebastian Staebler, Regina Ebert, Jürgen Seibel and Anja Katrin Boßerhoff
Modifying the Glycocalyx of Melanoma Cells via Metabolic Glycoengineering Using N-Acetyl-D-glucosamine Analogues
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Marcel Rühling, Louise Kersting, Fabienne Wagner, Fabian Schumacher, Dominik Wigger, Dominic A. Helmerich, Tom Pfeuffer, Robin Elflein, Christian Kappe, Markus Sauer, Christoph Arenz, Burkhard Kleuser, Thomas Rudel, Martin Fraunholz & Jürgen Seibel
Trifunctional sphingomyelin derivatives enable nanoscale resolution of sphingomyelin turnover in physiological and infection processes via expansion microscopy
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Mingzhen Fan, Patrick Kiefer, Paul Charki, Christian Hedberg, Jürgen Seibel, Julia A. Vorholt and Hubert Hilbi
The Legionella autoinducer LAI-1 is delivered by outer membrane vesicles to promote interbacterial and interkingdom signaling
J. Biol. Chem. 2023, 299(12), 105376
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Christine Sternstein, Theresa-Maria Böhm, Julian Fink, Jessica Meyr, Martin Lüdemann, Melanie Krug, Kirill Kriukov, Cenk O. Gurdap, Erdinc Sezgin, Regina Ebert and Jürgen Seibel
Development of an Effective Functional Lipid Anchor for Membranes (FLAME) for the Bioorthogonal Modification of the Lipid Bilayer of Mesenchymal Stromal Cells
Bioconjugate Chem. 2023, 34, 7, 1221-12331
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Maria Elena Ortiz-Soto, Makarius Baier, Daniela Brenner, Malte Timm and Jürgen Seibel
Single-mutations at the galactose-binding site of enzymes GalK, GalU and LgtC enable the efficient synthesis of UDP-6-azido-6-deoxy-D-galactose and azido-functionalized Gb3 analogs
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Angela Münch, Lorenz Weihrich, Niclas Knoblauch and Prof. Dr. Jürgen Seibel
Employing Click Chemistry to Expand the Scope of the Metal-Free Donor-Acceptor Type Photocatalyst 4CzIPN
Eur. J. Org. Chem. 2023, 26, e202300279
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Daniela Brenner, Nina Geiger, Jan Schlegel, Viktoria Diesendorf, Louise Kersting, Julian Fink, Linda Stelz, Sibylle Schneider-Schaulies, Markus Sauer, Jochen Bodem, Jürgen Seibel
Azido-Ceramides, a Tool to Analyse SARS-CoV-2 Replication and Inhibition—SARS-CoV-2 Is Inhibited by Ceramides
Int. J. Mol. Sci. 2023, 24(8), 7281
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Jürgen Mut, Stephan Altmann, Sabine Reising, Jutta Meißner-Weigl, Marc D. Driessen, Regina Ebert, Jürgen Seibel
SiaNAl can be efficiently incorporated in glycoproteins of human mesenchymal stromal cells by metabolic glycoengineering
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Ahmed M. Sayed, Alyaa Hatem Ibrahim, Nasir Tajuddeen, Jürgen Seibel, Jochen Bodem, Nina Geiger, Kathrin Striffler, Gerhard Bringmann, Usama Ramadan Abdelmohsen
Korupensamine A, but not its atropisomer, korupensamine B, inhibits SARS-CoV-2 in vitro by targeting its main protease (Mpro)
Eur. J. Med. Chem. 2023, 251, 115226
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Christine Sternstein, Jan Schlegel, Markus Sauer, Jürgen Seibel
Bioorthogonal azido-S1P works as substrate for S1PR1,
J. Lipid Res. 2023, 64 (1), 100311
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Nina Geiger, Louise Kersting, Jan Schlegel, Linda Stelz, Sofie Fähr, Viktoria Diesendorf, Valeria Roll, Marie Sostmann, Eva-Maria König, Sebastian Reinhard, Daniela Brenner, Sibylle Schneider-Schaulies, Markus Sauer, Jürgen Seibel and Jochen Bodem
The Acid Ceramidase Is a SARS-CoV-2 Host Factor,
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Sascha Eder, Claudia Hollmann, Putri Mandasari, Pia Wittmann, Fabian Schumacher , Burkhard Kleuser, Julian Fink, Jürgen Seibel, Jürgen Schneider-Schaulies, Christian Stigloher, Niklas Beyersdorf and Sofia Dembski
Synthesis and Characterization of Ceramide-Containing Liposomes as Membrane Models for Different T Cell Subpopulations,
J. Funct. Biomater. 2022, 13(3), 111
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Sibylle Schneider-Schaulies, Fabian Schumacher, Dominik Wigger, Marie Schöl, Trushnal Waghmare, Jan Schlegel, Jürgen Seibel and Burkhard Kleuser
Sphingolipids: Effectors and Achilles Heals in Viral Infections?,
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Marco R. Rink, Marisa A. P. Baptista, Felix J. Flomm, Thomas Hennig, Adam W. Whisnant, Natalia Wolf, Jürgen Seibel, Lars Dölken, Jens B. Bosse
Concatemeric Broccoli reduces mRNA stability and induces aggregates,
PLoS ONE 2021, 16(8), e0244166
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Jürgen Seibel, Sibylle Schneider-Schaulies and Burkhard Kleuser
Editorial: Sphingolipids in Infection Control,
Front. Cell Dev. Biol. 2021, 9, 697290
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Florian Pinzner, Thorsten Keller, Jürgen Mut, Julian Bechold, Jürgen Seibel and Jürgen Groll
Polyoxazolines with a Vicinally Double-Bioactivated Terminus for Biomacromolecular Affinity Assessment,
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Melissa Zimniak, Luisa Kirschner, Helen Hilpert, Nina Geiger, Olga Danov, Heike Oberwinkler, Maria Steinke, Katherina Sewald, Jürgen Seibel and Jochen Bodem
The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in human lung tissue,
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Stephan Altmann, Jürgen Mut, Natalia Wolf, Jutta Meißner-Weigl, Maximilian Rudert, Franz Jakob, Marcus Gutmann, Tessa Lühmann, Jürgen Seibel and Regina Ebert
Metabolic Glycoengineering in hMSC-TERT as a Model for Skeletal Precursors by Using Modified Azide/Alkyne Monosaccharides,
Int. J. Mol. Sci. 2021, 22(6), 2820
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S. Peters, L. Kaiser, J. Fink, F. Schumacher, V. Perschin, J. Schlegel, M. Sauer, C. Stigloher, B. Kleuser, J. Seibel and A. Schubert-Unkmeir
Click-correlative light and electron microscopy (click-AT-CLEM) for imaging and tracking azido-functionalized sphingolipids in bacteria,
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Julian Fink, Fabian Schumacher, Jan Schlegel, Philipp Stenzel, Dominik Wigger, Markus Sauer, Burkhard Kleuser, and Jürgen Seibel
Azidosphinganine enables metabolic labeling and detection of sphingolipid de novo synthesis,
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Teresa Wiese, Fabio Dennstädt, Claudia Hollmann, Saskia Stonawski, Catherina Wurst, Julian Fink, Erika Gorte1, Putri Mandasari, Katharina Domschke, Leif Hommers, Bernard Vanhove, Fabian Schumacher10, Burkhard Kleuser, Jürgen Seibel, Jan Rohr, Mathias Buttmann, Andreas Menke, Jürgen Schneider- Schaulies, Niklas Beyersdorf
Inhibition of acid sphingomyelinase increases regulatory T cells in humans
Brain Communications, 2021,, fcab020, https://doi.org/10.1093/braincomms/fcab020
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Ralph Götz, Tobias Kunz, Julian Fink, Franziska Solger, Jan Schlegel, Jürgen Seibel, Vera Kozjak-Pavlovic, Thomas Rudel, Markus Sauer
Nanoscale imaging of bacterial infections by sphingolipid expansion microscopy
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Fink J., Seibel J., Avota E.
Detection of Functionalized Sphingolipid Analogs in Detergent-Resistant Membranes of Immune Cells
In: Bieberich E. (eds) Lipid Rafts. Methods in Molecular Biology, vol 2187. Humana, New York, NY
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N. Wolf, L. Kersting, C. Herok, C. Mihm, J. Seibel
High Yielding Water-Soluble Asymmetric Cyanine Dyes for Labeling Applications
J. Org. Chem.. 2020, 85, 9751–9760.
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P.J. Smith, M.E. Ortiz-Soto, C. Roth, W. J. Barnes, J. Seibel, B. R. Urbanowicz, F. Pfrengle
Enzymatic Synthesis of Artificial Polysaccharides
ACS Sustainable Chem. Eng. 2020, 32, 11853–11871.
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K. Rajeeve, N. Vollmuth, S. Janaki-Raman, T. Wulff, M. Schmalhofer, W. Schmitz, A. Baluapuri, C. Huber, J. Fink, F. R. Dejure, E. Wolf, W. Eisenreich, A. Schulze, J. Seibel, T. Rudel
Nature Microbiology 2020, 5, 1390–1402.
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ME Ortiz-Soto, JR Porras-Domínguez, ME Rodríguez-Alegría, LA Morales-Moreno, A Díaz-Vilchis, E Rudiño-Piñera, NE Beltrán-Hernandez, HM Rivera, J Seibel, A López Munguía
Int. J. Biol. Macromolecules 2020, 161, 898-908.
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F. Solger, T. C. Kunz, J. Fink, F. Schumacher, K. Paprotka, P. Pfister, F. Hagen, B. Kleuser, J. Seibel, T. Rudel
A role of sphingosine in the intracellular survival of Neisseria gonorrhoeae
Front. Cell. Infect. Microbiol. 2020, 10, 250, doi.10.3389/fcimb.2020.00215
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Judith Lang, Patrick Bohn, Hilal Bhat, Holger Jastrow, Bernd Walkenfort, Feyza Cansiz, Julian Fink, Michael Bauer, Dominik Olszewski, Ana Ramos-Nascimento, Vikas Duhan, Sarah-Kim Friedrich, Katrin Anne Becker, Adalbert Krawczyk, Michael J. Edwards, Andreas Burchert, Magdalena Huber, Justa Friebus-Kardash, Joachim R. Göthert, Cornelia Hardt, Hans Christian Probst, Fabian Schumacher, Karl Köhrer, Burkhard Kleuser, Eduard B. Babiychuk, Beate Sodeik, Jürgen Seibel, Urs F. Greber, Philipp A. Lang, Erich Gulbins & Karl S. Lang
Nat Commun 2020, 11, 1338. doi:10.1038/s41467-020-15072-8
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M. E. Ortiz-Soto, S. Reising, A. Schlosser, J. Seibel
Sci Rep 2019, 9, 17993, doi:10.1038/s41598-019-54384-8
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C. Hollmann, T. Wiese, F. Dennstädt, J. Fink, J. Schneider-Schaulies, N. Beyersdorf
Fron. Immunol. 2019, https://doi.org/10.3389/fimmu.2019.02363.
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T Wiese, F Dennstaedt, C Hollmann, S Stonawski, C Wurst, J Fink, J Seibel, J Rohr, M Buttmann, A Menke, J Schneider-Schaulies, N Beyersdorf
CD4+ Foxp3+ regulatory T cell-mediated immunomodulation by pharmacological inhibition of the acid sphingomyelinase in humans
EUROPEAN JOURNAL OF IMMUNOLOGY 2019, 49, 283.
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V. Merz, J. Lenhart, Y. Vonhausen, M. E. Ortiz‐Soto, J. Seibel, A. Krueger
Nanodiamond with Superior Protein Repulsion and Colloidal Stability in Physiological Media
Small 2019, 15(48):e1901551. doi: 10.1002/smll.201901551.
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G. Beliu, A. Kurz, A. Kuhlemann, L. Behringer-Pliess, N. Wolf, J. Seibel, Zhen-Dan Shi, M. Schnermann, J. B. Grimm, L. D. Lavis, S. Doose, M. Sauer
Bioorthogonal labeling with tetrazine-dyes for super-resolution microscopy
Commun Biol. 2019, 2, 261. doi: 10.1038/s42003-019-0518-z. eCollection 2019.
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M. E. Ortiz-Soto, J.R. Porras-Domínguez, J. Seibel, A. López-munguía
Carbohydrat Polymers 2019, 219, 130-142.
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C. Possiel, M. E. Ortiz-Soto, J. Ertl, A. Münch, A. Vogel, R. Schmiedel, J. Seibel
Scientific Reports 2019, 9, 7720.
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L. Irsheid, T. Wehler, C. Borek, W. Kiefer, R. Brenk, M. E. Ortiz-Soto, J. Seibel, T. Schirmeister
PLoS ONE 2019, 14 (5), e0216132.
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J. Ertl, M. E. Ortiz-Soto, T. A. Le, J. Bechold, J. Shan, J. Teßmar, B. Engels, J. Seibel
Chemistry - A European Journal 2019, 25, 6533-6541.
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M. Gutmann, J. Bechold, J. Seibel, L. Meinel, T. Lühmann
ACS Biomater. Sci. Eng. 2019, 5 (1), 215–233.
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D. Kaiser, J. M. Winne, M. E. Ortiz-Soto, J. Seibel, T. Anh Le, B. Engels
Mechanistical insights into the bioconjugation reaction of Triazolinediones with tyrosine
J. Org. Chem. 2018, 83, 10248–10260.
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M. Kraus, C. Grimm, J. Seibel
Scientific Reports 2018, 8, 10490.
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M. E. Ortiz-Soto, J. Ertl, J. Mut, J. Adelmann, T. A. Le, J. Shan, J. Teßmar, A. Schlosser, B. Engels, J. Seibel
Product-oriented chemical surface modification of a levansucrase (SacB) via an ene-type reaction
Chem. Sci. 2018, 9, 5312-5321.
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J. Fink, J. Seibel
Click reactions with functional Sphingolipids
Biol. Chem. 2018, 399(10), 1157-1168.
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M. Gutmann, A. Braun, J. Seibel, T. Lühmann
Bioorthogonal modification of cell derived matrices by metabolic glyco-engineering
ACS Biomaterials Science & Engineering 2018, 4, 1300-1306.
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J. Seibel, C. Grimm, J. Bechold
Nachrichten aus der Chemie 2018, 66 (1), 30-31.
J. Becam, T. Walter, A. Burgert, J. Schlegel, M. Sauer, J. Seibel, A. Schubert-Unkmeir
Antibacterial activity of ceramide and ceramide analogs against pathogenic Neisseria
Scientific Reports 2017, 7, Article number: 17627 (2017)
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M. Kraus, C. Grimm, J. Seibel
Switching enzyme specificity from phosphate to resveratrol glucosylation
Chem. Commun. 2017, 53, 12181 - 12184.
C. Possiel, A. Bäuerle, J. Seibel
A novel Chemoenzymatic route to a new class of Sucrose esters
Eur. J. Org. Chem. 2017, 6335–6337.
J. Görl, C. Possiel, C. Sotriffer, J. Seibel,
ChemBioChem 2017, 18, 2012-2015.
M. Elena Ortiz-Soto, C. Possiel, J. Görl, A. Vogel, R. Schmiedel, J. Seibel
Glycobiology 2017, 27, 755-765.
N. Bertleff-Zieschang, J. Bechold, C. Grimm, M. Reutlinger, P. Schneider, G. Schneider, J. Seibel
Exploring the structural space of galectin-1-ligand interaction
ChemBioChem 2017, 18, 1477-1481.
T. Walter, J. Schlegel, A. Burgert, A. Kurz, J. Seibel and M. Sauer
Incorporation studies of clickable ceramides in Jurkat cell plasma membranes
Chem. Commun. 2017, 53, 6836-6839.
M. Ortiz-Soto, J. Seibel
Molecular Engineering of Enzymes
Applied Bioengineering: Innovations and Future Directions 2017
Stephan Wawra, Philipp Fesel, Heidi Widmer, Malte Timm, Jürgen Seibel, Lisa Leson, Leona Kesseler, Robin Nostadt, Magdalena Hilbert, Gregor Langen & Alga Zuccaro
The fungal-specific β-glucan-binding lectin FGB1 alters cell-wall composition and suppresses glucan-triggered immunity in plants
Nat. Commun. 2016, 7, 13188.
A. Mertsch, S. Letschert, E. Memmel, M. Sauer, J. Seibel
Synthesis and application of water soluble, photoswitchable cyanine dyes for bioorthogonal labeling of cell-surface carbohydrates
Biosciences – Zeitschrift für Naturforschung C 2016, 71, 347–354.
J. Seibel
ZNC opens a new chapter focussing on the emerging field of natural and natural-like compounds
Biosciences – Zeitschrift für Naturforschung C 2016, 71, 93
M. Ortiz-Soto, J. Seibel
From gene to product: tailor-made oligosaccharides and polysaccharides by enzyme and substrate engineering
Carbohydrate-Modifying Biocatalysts 2016, 535
T. Walter, L. Collenburg, L. Japtok, B. Kleuser, S. Schneider-Schaulies, N. Müller, J. Becam, A. Schubert-Unkmeir, J. N. Konge, E. Bieberich and J. Seibel
Incorporation and visualization of azido-functionalized N-oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells
Chem. Commun. 2016, 52, 8612-8614
M. Ortiz-Soto, J. Seibel
Expression of Functional Human Sialyltransferases ST3Gal1 and ST6Gal1 in Escherichia coli
PLoS One 2016, 11, e0155410.
L. Collenburg, T. Walter, A. Burgert, N. Müller, J. Seibel, L. Japtok, B. Kleuser, M. Sauer, S. Schneider-Schaulies
A Functionalized Sphingolipid Analogue for Studying Redistribution during Activation in Living T Cells
J. Immunol. 2016, 196, 3951-3962.
M. Kraus, J. Görl, M. Timm, J. Seibel
Synthesis of the rare disaccharide nigerose by structure-based design of a phosphorylase mutant with altered regioselectivity
Chem. Commun. 2016, 52, 4625-4627.
M. Gutmann, E. Memmel, A. Braun, J. Seibel, L. Meinel, T. Lühmann
Biocompatible azide alkyne"click" reactions for surface decoration of glyco-engineered cells
ChemBioChem 2016, 17, 866-875.
M. Kraus, C. Grimm, J. Seibel
Redesign of the active site of sucrose phosphorylase by a clash induced cascade of loop shifts
ChemBioChem 2016, 17, 33–36.
C. Fleck, E. Memmel, M. Fölsing, B. Poll, T. Hackl, J. Seibel, W. Maison
Synthesis and evaluation of neoglycoconjugates based on adamantyl scaffolds.
Eur. J. Org. Chem. 2015, 8, 1696–1710.
E. Memmel, J. Seibel
Metabolic Engineering of Bacteria.
in Proceedings of the 3rd Beilstein Glyco-Bioinformatics Symposium 2013 (Herausgeber M. G. Hicks, C. Kettner, P. Seeberger)
Beilstein Institut, Frankfurt/Main 2014, 1-9.
D. Claes, E. Memmel, M. Holzapfel, J. Seibel, W. Maison
High-Affinity Carbohydrate Binding by Trimeric Benzoboroxoles Measured on Carbohydrate Arrays.
ChemBioChem 2014, 15, 2450–2457.
S. Letschert, A. Göhler, C. Franke, N. Bertleff-Zieschang, E. Memmel, S. Doose, J. Seibel, M. Sauer
Super-Resolution Imaging of Plasma Membrane Glycans.
Angew. Chem. Int. Ed. 2014, 53(41), 10921–10924.
U. T. Bornscheuer, K. Buchholz, J. Seibel
Enzymatic degradation of (ligno-)celluloses.
Angew. Chem. Int. Ed. 2014, 53(41), 10876–10893.
S. Bank, E. Heller, E. Memmel, J. Seibel, U. Holzgrabe, P. Kapková
Matrix-assisted laser desorption/ionization tandem mass spectrometry of N-glycans derivatized with isonicotinic hydrazide and its biotinylated form.
Rapid Commun. Mass Spectrom. 2014, 28(15), 1745–1756.
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M. E. Ortiz-Soto, J. Seibel
Biotechnological Synthesis and Transformation of Valuable Sugars in the Food and Pharmaceutical Industry.
Current Organic Chemistry 2014, 18, 964–986.
