Silicon-Containing Drugs
Differences between Analogous Compounds of Carbon and Silicon
Shape and Size
Bonding Geometries
Conformational Flexibility
Charge Distribution
Lipophilicity
Chemical Reactivity, etc.
Biological Activity?
C/Si Bioisosterism?
Biological Sila-Substitution Effects?
Reviews: W. Bains, R. Tacke, Curr. Opin. Drug Discovery Dev. 2003, 6, 526–543.
R. Tacke, H. Linoh, in: The Chemistry of Organic Silicon Compounds, Part 2 (Eds.: S. Patai, Z. Rappoport), John Wiley & Sons Ltd., Chichester, 1989, 1143-1206.
Patents: D. Miller, G.A. Showell, R. Conroy, J. Daiss, R.Tacke, D. Tebbe (Amedis Pharmaceuticals Ltd.), PCT Int. Pat. Appl. WO 2005/005443 A1 (08.06.2004). more ...
J. G. Montana, A. G. Showell, I. Fleming, R. Tacke, J. Daiss (Inventors), Amedis Pharmaceuticals Ltd., Cambridge, U.K., PCT Int. Pat. Appl. WO 2004/048390 A1 (10.06.2004). more ...
J. G. Montana, G. A. Showell, R. Tacke (Inventors), Amedis Pharmaceuticals Ltd., Cambridge, U.K., PCT Int. Pat. Appl. WO 2004/048391 A1 (10.06.2004). more ...
J.G. Montana, I. Fleming, R.Tacke, J. Daiss (Amedis Pharmaceuticals Ltd.), PCT Int. Pat. Appl. WO 2004/045625 A1 (03.06.2004). more ...
