Intern
    Prof. Dr. Reinhold Tacke

    Sila-haloperidol

      

    Sila-haloperidol: A Silicon Analogue of the Dopamine Antagonist Haloperidol

     

    Synthesis of Sila-haloperidol

    Receptor Affinities of Haloperidol and Sila-haloperidol for the Dopamine hD1, hD2, hD3, hD4, and hD5 Receptor (Radioligand Binding Studies)

     

    Metabolism of Haloperidol and Sila-haloperidol

    Major in vitro Metabolites of Sila-haloperidol (Human Liver Microsomes, MS/MS Studies)

     

    R. Tacke, T. Heinrich, R. Bertermann, C. Burschka, A. Hamacher, M. U. Kassack, Organometallics 2004, 23, 4468–4477. more ...

    R. Tacke, F. Popp, B. Müller, B. Theis, C. Burschka, A. Hamacher, M. U. Kassack, D. Schepmann, B. Wünsch, U. Jurva, E. Wellner, ChemMedChem 2008, 3, 152–164. more...

    R. Tacke, T. Heinrich (Amedis Pharmaceuticals Ltd.), UK Pat. Appl. GB 2382575 A (04.06.2003). more...