Publications
Patric Komforth, Jan Imschweiler, Milena Hesse, Alina G. Heck, Alexander Fuchs, Adrian V. Hauck, Lutz Nuhn – "Toward Intracellular Delivery: Aliphatic Polycarbonates with Pendant Thiol-Reactive Thiosulfonates for Reversible Postpolymerization Modification", Biomacromolecules 2024, accepted, DOI: 10.1021/acs.biomac.4c01207.
Alexander Fuchs, Christian Czysch, Konrad Maxeiner, Pia Winterwerber, Sascha Schmitt, Judith Stickdorn, Zifu Zhong, Carolina Medina-Montano, Hans-Joachim Räder, Matthias Bros, Bruno G. De Geest, Kaloian Koynov, Stephan Grabbe, Lutz Nuhn – "Introducing Degradable Cationic Nanogels Carrying TLR9 Stimulating Oligonucleotides", Small 2024, accepted, DOI: 10.1002/smll.202406082.
Adrian V. Hauck, Patric Komforth, Jessica Erlenbusch, Krzysztof Radacki, Holger Braunschweig, Pol Besenius, Simon B. Van Herck, Lutz Nuhn – “Aliphatic poly(carbonates) with acid degradable ketal side groups as pH responsive smart immunodrug nanocarriers”, Biomaterials Science 2024, accepted, DOI: 10.1039/D4BM00949E.
Leon Bixenmann, Taufiq Ahmad, Faban Stephan, Lutz Nuhn – “End-Group Dye-Labeled Poly(hemiacetal ester) Block Copolymers: Enhancing Hydrolytic Stability and Loading Capacity for Micellar (Immuno-)Drug Delivery“, Biomacromolecules 2024, accepted, DOI: 10.1021/acs.biomac.4c01229.
Zifu Zhong, Marie H. Deventer, Yong Chen, Stijn Vanhee, Inés Lammens, Kim Deswarte, Yi Huang, Tingting Ye, Haixiu Wang, Lutz Nuhn, Marthe Vandeputte, Mark Gontsarik, Xiaole Cui, Niek N. Sanders, Stefan Lienenklaus, Bart N. Lambrecht, Christophe P. Stove, Antonio P. Baptista, Bruno De Geest – "A Fentanyl Hapten-Displaying Lipid Nanoparticle Vaccine that Non-Covalently Encapsulates a TLR7/8 Agonist and T-helper Epitope Induces Protective Anti-Fentanyl Immunity", Angewandte Chemie International Edition 2024, accepted, DOI: 10.1002/anie.202419031; Angewandte Chemie 2024, accepted, DOI: 10.1002/ange.202419031.
Alina G. Heck, Carolina Medina-Montano, Zifu Zhong, Kim Deswarte, Katharina Eigen, Judith Stickdorn, Johannes Kockelmann, Maximilian Scherger, Niek N. Sanders, Stefan Lienenklaus, Bart N. Lambrecht, Stephan Grabbe, Bruno G. De Geest, Lutz Nuhn* – "PH-Triggered, Lymph Node Focused Immunodrug Release by Polymeric 2-Propionic-3-Methylmaleic Anhydrides with Cholesteryl End Groups", Advanced Healthcare Materials 2024, accepted, DOI: 10.1002/adhm.202402875.
Alina G. Heck, Lutz Nuhn* – "Restoring the pH-Responsiveness for Amine-Conjugated 2-Propionic-3-Methylmaleic Anhydride Linkers", Organic Chemistry Frontiers 2024, 11, 4380-4384.
Alina G. Heck, David Schwiertz, Bellinda Lantzberg, Ha-Chi Nguyen, Robert Forster, Maximilian Scherger, Till Opatz, Jo A. Van Ginderachter, Lutz Nuhn* – "Introducing Targeting Units or pH-Releasable Immunodrugs into Core-Clickable Nanogels", European Polymer Journal 2024, 214, 113150.
Maximilian Scherger, Yannick A. Pilger, Patric Komforth, Hans-Joachim Räder, Lutz Nuhn* – “Reversible Polymer-Protein Functionalization by Step-Wise Introduction of Amine-reactive, Reductive-Responsive Self-Immolative End Groups onto RAFT-derived Polymers”, ACS Biomaterials Science & Engineering 2024, 10, 129-138.
Alina G. Heck, Judith Stickdorn, Laura J. Rosenberger, Maximilian Scherger, Jonas Woller, Katharina Eigen, Matthias Bros, Stephan Grabbe, Lutz Nuhn* – "Polymerizable 2Propionic-3-methylmaleic Anhydrides as a Macromolecular Carrier Platform for pH-Responsive Immunodrug Delivery", Journal of the American Chemical Society 2023, 145, 27424–27436.
Johannes Kockelmann, Rudolf Zentel,* Lutz Nuhn* – “Post-polymerization modifications to prepare biomedical nanocarriers with varying internal structures, their propertiesand impacton protein corona formation”, Macromolecular Chemistry and Physics 2023, 224, 2300199.
Maximilian Scherger, Yannick A. Pilger, Judith Stickdorn, Patric Komforth, Sascha Schmitt, Sana Arnouk, Els Lebegge, Kaloian Koynov, Hans-Joachim Räder, Jo A. Van Ginderachter, Lutz Nuhn* – “Self-Immolative Nanobody-Cysteine Residue Modification for Controlled Immunodrug Delivery”, Advanced Therapeutics 2023, 6, 2300076 (Selected by ChemMedChem 2023 for their article series Hot Topic: Drug Delivery).
Judith Stickdorn, Christian Czysch, Carolina Medina-Montano, Lara Stein, Lujuan Xu, Maximilian Scherger, Hansjörg Schild, Stephan Grabbe, Lutz Nuhn* – "Peptide-Decorated Degradable Polycarbonate Nanogels for Eliciting Antigen-Specific Immune Responses", International Journal of Molecular Sciences 2023, 24, 15417.
Lutz Nuhn* – “Artificial intelligence assists nanoparticles to enter solid tumours”, Nature Nanotechnology 2023, 18, 550-551 (News & Views).
Maximilian Scherger, Yannick A. Pilger, Judith Stickdorn, Patric Komforth, Sascha Schmitt, Kaloian Koynov, Hans-Joachim Räder, Lutz Nuhn* – “Efficient Self-Immolative RAFT End Group Modification for Macromolecular Immunodrug Delivery”, Biomacromolecules 2023, 24, 2380-2391.
Adrian Prudlik, Nayereh Mohebatti, Laura Hildebrandt, Alina Heck, Lutz Nuhn, Robert Francke – “TEMPO-Modified Polymethacrylates as Mediators in Electrosynthesis - Influence of the Molecular Weight on Redox Properties and Electrocatalytic Activity”, Chemistry – A European Journal 2023, 29, e202202730.
Christian Czysch, Thi Dinh, Yannick Fröder, Leon Bixenmann, Patric Komforth, Alexander Balint, Hans-Joachim Räder, Stefan Naumann, Lutz Nuhn* – “Non-toxic N-heterocyclic Olefin Catalyst Systems for Well-Definded Polymerization of Biocompatible Aliphatic Polycarbonates”, ACS Polym. AU 2022, 2, 371-379 (selected for the Raising Stars in Polymers 2022 Series).
Anne Huppertsberg, Christian Leps, Irina Alberg, Christine Rosenauer, Svenja Morsbach, Katharina Landfester, Stefan Tenzer, Rudolf Zentel, Lutz Nuhn* – “Squaric ester-based nanogels provide no specific protein corona but behave as hydrogels that incorporate plasma proteins“, Macromolecular Rapid Communications 2022, 43, 202200318 (Frontcover of Macromolecular Rapid Communication 2022 Vol. 43, issue 19 and selected by ChemMedChem 2022 for their article series Hot Topic: Drug Delivery).
Christian Czysch, Carolina Medina-Montano, Zifu Zhong, Alexander Fuchs, Judith Stickdorn, Pia Winterweber, Sascha Schmitt, Kim Deswarte, Macro Raabe, Maximilian Scherger, Francis Combes, Jana De Vrieze, Sabah Kasmi, Niek N. Sandners, Stefan Lienenklaus, Kaloian Koynov, Hans-Joachim Räder, Bart N. Lambrecht, Sunil A. David, Matthias Bros, Hansjörg Schild, Stefan Grabbe, Bruno G. De Geest, Lutz Nuhn* – “Transient Lymph Node Immune Activation by Hydrolysable Poly(carbonate) Nanogels”, Advanced Functional Materials 2022, 32, 202203490.
Christian Czysch, Carolina Medina-Montano, Nils-Jørgen Knudsen Dal, Thi Dinh, Yannick Fröder, Pia Winterweber, Konrad Maxeiner, Hans-Joachim Räder, Detlef Schuppan, Hansjörg Schild, Matthias Bros, Bernhard Biersack, Federico Feranoli, Stephan Grabbe, Lutz Nuhn* – “End Group Dye-Labeled Polycarbonate Block Copolymers for Micellar (Immuno-)Drug Delivery”, Macromolecular Rapid Communications 2022, 43, 202200095.
Sascha Schmitt, Lutz Nuhn, Matthias Barz, Hans-Jürgen Butt, Kaloian Koynov – “Shining light on Polymeric Drug Nanocarriers with Fluorescence Correlation Spectroscopy”, Macromolecular Rapid Communications 2022, 43, 202100892.
Matthias Barz,* Lutz Nuhn,* Gerhard Hörpel, Rudolf Zentel – “From Self-Organization to Tumor-Immune therapy: How things started and how they evolved“, Macromolecular Rapid Communications 2022, 43, 202100829.
Matthias Barz,* Lutz Nuhn,* Patrick Theato* – “A Tribute to Rudolf Zentel and His Lifetime Research Achievements”, Macromolecular Rapid Communications 2022, 43, 2200311(Guest Editor in Macromolecular Rapid Communications 2022, Vol. 43, Issue 12, Special Issue: A Tribute to Rudolf Zentel).
Leonard Kaps, Anne Huppertsberg, Niklas Choteschovsky, Adrian Klefenz, Feyza Durak, Barbara Schrörs, Mustafa Diken, Emma Eichler, Sebastian Rosigkeit, Sascha Schmitt, Christian Leps, Alicia Schulze, Friedrich Foerster, Ernesto Bockamp, Bruno G. De Geest, Kaloian Koynov, Hans-Joachim Räder, Stefan Tenzer, Federico Marini, Detlef Schuppan,* Lutz Nuhn* – “pH-Degradable, Bisphosphonate-Loaded Nanogels Attenuate Liver Fibrosis by Repolarization of M2-type Macrophages”, Proceedings of the National Academy of Sciences 2022, 119, e2122310119.
Judith Stickdorn, Lara Stein, Danielle Arnold-Schild, Jennifer Hahlbrock, Carolina Medina-Montano, Joschka Bartneck, Tanja Ziß, Evelyn Montermann, Cinja Kappel, Dominika Hobernik, Maximilian Haist, Hajime Yurugi, Marco Raabe, Andreas Best, Krishnaraj Rajalingam, Markus P. Rasak, Sunil A. David, Kaloian Koynov, Matthias Bros, Stephan Grabbe,* Hansjörg Schild,* Lutz Nuhn* – “Systemically Administered TLR7/8-Agonist- and Antigen Conjugated Nanogels Govern Immune Responses against Tumors”, ACS Nano 2022, 16, 4426-4443 (Supplementary Cover of ACS Nano 2022, Vol. 16, Issue 3).
Sascha Schmitt, Anne Huppertsberg, Adrian Klefenz, Leonard Kaps, Volker Mailänder, Detlef Schuppan, Hans-Jürgen Butt, Lutz Nuhn,* Kaloian Koynov* – “Fluorescence Correlation Spectroscopy Monitors the Fate of Degradable Nanocarriers in the Blood Stream“, Biomacromolecules 2022, 23, 1065-1074.
Marco Raabe, Astrid Johanna Heck, Siska Führer, Dominik Schauenburg, Michaela Pieszka, Tao Wang, Maksymilian Marek Zegota, Lutz Nuhn, David Y. W. Ng, Seah Ling Kuan, Tanja Weil – “Assembly of pH-Responsive Antibody-Drug-Inspired Conjugates”, Macromolecular Bioscience 2022, 22, 2100299.
Cinja Kappel, Christine Seidl, Carolina Medina-Montano, Meike Schinnerer, Irina Alberg, Christian Leps, Julian Sohl, Ann-Kathrin Hartmann, Michael Fichter, Michael Kuske, Jenny Schunke, Gabor Kuhn, Ingrid Tubbe, David Paßlick, Dominika Hobernik, Rebekka Bent, Katharina Haas, Evelyn Montermann, Kerstin Walzer, Mustafa Diken, Manfred Schmidt, Rudolf Zentel, Lutz Nuhn, Hansjörg Schild, Stefan Tenzer, Volker Mailänder, Matthias Barz, Matthias Bros, Stephan Grabbe – “Density of Conjugated Antibody Determines the Extent of Fc Receptor Dependent Capture of Nanoparticles by Liver Sinusoidal Endothelial Cells”, ACS Nano 2021, 15, 15191-15209.
Jana De Vrieze, Antonio P. Baptista, Lutz Nuhn, Simon Van Herck, Kim Deswarte, Haijun Yu, Bart N. Lambrecht, Bruno G. De Geest – “Lipid nature and alkyl length influence lymph node accumulation of lipid-PEG amphiphiles“, Advanced Therapeutics 2021, 4, 2100079.
Anne Huppertsberg, Leonard Kaps, Zifu Zhong, Sascha Schmitt, Judith Stickdorn, Kim Deswarte, Francis Combes, ChristianCzysch, Jana De Vrieze, Sabah Kasmi, Niklas Choteschovsky, Adrian Klefenz, Carolina Medina-Montano, Pia Winterwerber, Chaojian Chen, Matthias Bros, Stefan Lienenklaus, Niek N. Sanders, Kaloian Koynov, Detlef Schuppan, Bart N. Lambrecht, Sunil David, Bruno G. De Geest, Lutz Nuhn* – “Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-Like Receptor 7/8 Agonistic Immune Modulators”, Journal of the American Chemical Society 2021, 143, 9872-9883.
Evangelia Bolli, Maximilian Scherger, Sana M. Arnouk, Ana Rita Pombo Antunes, David Straßburger, Moritz Urschbach, Judith Stickdorn, Karen De Vlaminck, Kiavash Movahedi, Hans Joachim Räder, Sophie Hernot, Pol Besenius, Jo A. Van Ginderachter*, Lutz Nuhn* – “Targeted Repolarization of Tumor-associated Macrophages via Imidazoquinoline-linked Nanobodies”, Advanced Science 2021, 8, 202004574 (Selected by ChemMedChem 2021 for their article series Hot Topic: Drug Delivery).
Maximilian Scherger, Hans Joachim Räder, Lutz Nuhn* – “Self-immolative RAFT-polymer end group modification”, Macromolecular Rapid Communication 2021, 42, 202000752(Backcover of Macromolecular Rapid Communication 2021 Vol. 42, issue 8 and selected for the Young Talents in Polymer Science 2020 Collection).
Sonia Jangra, Jana De Vrieze, Angela Choi, Raveen Rathnasinghe, Gabriel Laghlali, Annemiek Uvyn, Simon Van Herck, Lutz Nuhn, Kim Deswarte, Zifu Zhong, Niek N. Sanders, Stefan Lienenklaus, Sunil David, Shirin Strohmeier, Fatima Amanat, Florian Krammer, Hamida Hammad, Bart N. Lambrecht, Lynda Coughlan, Adolfo García-Sastre, Bruno G. De Geest, Michael Schotsaert – “Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine”, Angewandte Chemie International Edition 2021, 60, 9467-9473; Angewandte Chemie 2021, 133, 9553-9559.
Maximilian Scherger, Evangelia Bolli, Ana Rita Pompo Antunes, Sana Arnouk, Judith Stickdorn, Alexandra Van Driessche, Stephan Grabbe, Hansjörg Schild, Bruno G. De Geest, Jo A. Van Ginderachter,* Lutz Nuhn* – “Transient multivalent nanobody targeting to CD206-expressing cells via pH-degradable nanogels”, Cells 2020, 9, 2222.
Jana De Vrieze, Simon Van Herck, Lutz Nuhn, Bruno De Geest – “Design of pH-degradable polymer-lipid amphiphiles using a ketal-functionalized RAFT chain transfer agent”, Macromolecular Rapid Communications 2020, 41, 2000034.
Natalie Fuchs, Mergim Meta, Detlef Schuppan,* Lutz Nuhn,* Tanja Schirmeister* – “Novel Opportunities for Cathepsin S Inhibitors in Cancer Immmunotherapy by Nanocarrier-mediated Delivery”, Cells 2020, 9, 2021.
Hui Li, Simon Van Herck, Yongjun Liu, Yanyun Hao, Xiaochu Ding, Lutz Nuhn, Zifu Zhong, Francis Combes, Niek N. Sanders, Stefan Lienenklaus, Stefaan De Koker, Sunil A. David, Yadong Wang, Bruno G. De Geest, Zhiyue Zhang – “Imidazoquinoline-conjugated Degradable Coacervate Conjugate for Local Cancer Immunotherapy”, ACS Biomaterials Science & Engineering 2020, 6, 4993-5000.
Leonard Kaps, Nadine Leber, Adrian Klefenz, Niklas Choteschovsky, Rudolf Zentel, Lutz Nuhn,* Detlef Schuppan*– “In Vivo siRNA Delivery to Immunosuppressive Liver Macrophages by α-Mannosyl-Functionalized Cationic Nanohydrogel Particles”, Cells 2020, 9, 1905.
Thorsten Lückerath, Kaloian Koynov, Sebastian Loescher, Colette J. Whitfield, Lutz Nuhn, Andreas Walther, Christopher Barnerr-Kowollik, David Y. W. Ng, Tanja Weil – “DNA-Polymer Nanostructures by RAFT Polymerization and Polymerization-Induced Self-Assembly“, Angewandte Chemie International Edition 2020, 59, 15474-15497; Angewandte Chemie 2020, 132, 15602-15607.
Johannes Kockelmann, Judith Stickdorn, Sabah Kasmi, Jana De Vrieze, Michaela Pieszka, David Y. W. Ng, Sunil A. David, Bruno G. De Geest, Lutz Nuhn* – “Control over Immune Stimulation by pH-Degradable Poly(norbornene) Nanogels“, Biomacromolecules 2020, 21, 2246-2257.
Leon Bixenmann, Judith Stickdorn, Lutz Nuhn* – “Amphiphilic Poly(esteracetal)s as Dual pH-Responsive Micellar Immunodrug Delivery Systems”, Polymer Chemistry 2020, 11, 2441-2456 (selected for the Polymer Chemistry 2020 Emerging Investigators Collection).
Ruben Re Coen, Lutz Nuhn, Chamani Perera, Maria Arista Romero, Martijn Risseeuw, Alec Freyn, Raffael Nachbagauer, Lorenzo Albertazzi, Serge Van Calenbergh, David A. Spiegel, Blake R. Peterson, Bruno G. De Geest – “A Synthetic Rhamnose Glycopolymer as Cell Surface Receptor for Endogenous Antibody Recruitment”, Biomacromolecules 2020, 21,793-802.
Judith Stickdorn, Lutz Nuhn* – “Reactive ester derived nanogels for cancer immunotherapy”, European Polymer Journal 2020, 124, 109481.
Jana De Vrieze, Benoit Louage, Kim Deswarte, Zifu Zhong, Ruben De Coen, Simon Van Herck, Lutz Nuhn, Camilla Kaas Frich, Alexander N. Zelikin, Stefan Lienenklaus, Niek N. Sanders, Bart N. Lambrecht, Sunil A. David, Bruno G. De Geest – “Potent lymphatic translocation and spatial control over innate immune activation by polymer-lipid amphiphile conjugates of small molecule TLR7/8 agonists”, Angewandte Chemie International Edition 2019, 58, 15390-15395; Angewandte Chemie 2019, 131, 15535-15541.
Ruben De Coen, Lutz Nuhn, Bruno G. De Geest – “Engineering mannosylated nanogels with membrane-disruptive properties“, Polymer Chemistry 2019, 10, 4297-4304.
Nadine Leber, Leonard Kaps, Aiting Yang, Misbah Aslam, Mariacristina Giardino, Sebastian Rosigkeit, Asmaa Mostafa, Lutz Nuhn,* Detlef Schuppan,* Rudolf Zentel* – “α-Mannosyl-Functionalized Cationic Nanohydrogel Particles for Targeted Gene Knockdown in Immunosuppressive Macrophages”, Macromolecular Bioscience 2019, 19, 1900162 (Frontcover of Macromolecular Bioscience 2019, Vol. 19, Issue 7).
Zhiyue Zhang, Hui Li, Sabah Kasmi, Simon Van Herck, Kim Deswarte, Bart N. Lambrecht, Richard Hoogenboom, Lutz Nuhn, Bruno G. De Geest – “Synthetic Transiently Thermoresponsive Homopolymer with UCST Behavior within a Physiologically Relevant Window”, Angewandte Chemie International Edition 2019, 58, 7866-7872; Angewandte Chemie 2019, 131, 7948-7954.
Alexandra Van Driessche, Agnese Kocere, Hannelien Everaert, Lutz Nuhn, Simon Van Herck, Gareth Griffiths, Federico Felaroli, Bruno G. De Geest – “pH-Sensitive Hydrazone Linked Doxorubicin-Nanogels via Polymeric-Activated Ester Scaffolds: Synthesis, Assembly, and In Vitro and In Vivo Evaluation in Tumor-Bearing Zebrafish“, Chemistry of Materials 2018, 30, 8587−8596.
Simon Van Herck, Kim Deswarte, Lutz Nuhn, Zifu Zhong, Joao Portela Catani, Yupeng Li, Niek N. Sanders, Stefan Lienenklaus, Stefaan De Koker, Bart N. Lambrecht, Sunil A. David, Bruno G. De Geest – “Lymph node targeted immune-activation by small molecule TLR7/8 agonists conjugated to highly stable acid-degradable block copolymer amphiphiles”, Journal of the American Chemical Society 2018, 140, 14300-14307.
Lien Lybaert, Karim Vermaelen, Bruno G. De Geest,* Lutz Nuhn* – “Immunoengineering through Cancer Vaccines – a Personalized and Multi-step Vaccine Approach towards Precise Cancer Immunity”, Journal of Controlled Release 2018,289, 125-145.
Lutz Nuhn and Stefaan De Koker and Sandra Van Lint, Zifu Zhong, João Portela Catani, Francis Combes, Kim Deswarte, Yupeng Li, Bart N. Lambrecht, Stefan Lienenklaus, Niek N. Sanders, Sunil A. David, Jan Tavernier, Bruno G. De Geest – “Nanoparticle-conjugated TLR7/8 Agonist Localized Immunotherapy Provokes Safe and Synergistic Antitumoral Responses”, Advanced Materials 2018, 30, 1803397.
Matthias Bros, Lutz Nuhn, Johanna Simon, Lorna Moll, Volker Mailänder, Katharina Landfester, Stephan Grabbe – “The Protein Corona as a Confounding Variable of Nanoparticle-mediated Targeted Vaccine Delivery“, Frontiers in Immunology 2018, 9, 1760.
Lutz Nuhn* and Simon Van Herck, Andreas Best, Kim Deswarte, Maria Kokkinopoulou, Ingo Lieberwirth, Kaloian Koynov, Bart N. Lambrecht, Bruno G. De Geest* – “FRET Monitoring of Intracellular Ketal Hydrolysis in Synthetic Nanoparticles”, Angewandte Chemie International Edition 2018, 57, 10760-10764; Angewandte Chemie 2018, 130, 10920-10925.
Lutz Nuhn* and Evangelia Bolli, Sam Massa, Isabel Vandenberghe, Kiavash Movahedi, Bart Devreese, Jo A. Van Ginderarchter,* Bruno G. De Geest* – “Targeting Protumoral Tumor-associated Macrophages with Nanobody-functionalized Nanogels through SPAAC Ligation”, Bioconjugate Chemistry 2018, 29, 2394-2405.
Lutz Nuhn, Lien Van Hoecke, Kim Deswarte, Bert Schepen, Yupeng Li, Bart N. Lambrecht, Stefaan De Koker, Sunil A. David, Xavier Saelens, Bruno G. De Geest – “Potent Anti-Viral Vaccine Adjuvant Based on pH-Degradable Nanogels with Covalently Linked Small Molecule Imidazoquinoline TLR7/8 Agonist”, Biomaterials 2018, 178, 643-651.
Simon Van Herck, Lien Van Hoecke, Benoit Louage, Lien Lybaert, Ruben De Coen, Sabah Kasmi, Aaron P. Esser-Kahn, Sunil A. David, Lutz Nuhn, Bert Schepens, Xavier Saelens, Bruno G. De Geest “Transiently Thermoresponsive Acetal Polymers for Safe and Effective Administration of Amphotericin B as a Vaccine Adjuvant”, Bioconjugate Chemistry 2018, 29, 748-760.
Sabah Kasmi, Benoit Louage, Lutz Nuhn, Glenn Verstraete, Simon Van Herck, Mies van Steenbergen, Chris Vervaet, Wim E. Hennink, Bruno G. De Geest – “Acrylamides with hydrolytically labile carbonate ester side chains as versatile building blocks for well-defined block copolymer micelles via RAFT polymerization”, Polymer Chemistry 2017, 8, 6544-6557.
Nadine Leber, Lutz Nuhn, Rudolf Zentel – “Cationic Nanohydrogel Particles For Therapeutic Oligonucleotide Delivery”, Macromolecular Bioscience 2017, 17, 1700092.
Wouter Grymonpré, Nils Bostijn, Simon Van Herck, Glenn Verstraete, Valérie Vanhoorne, Lutz Nuhn, Pieter Rombouts, Thomas De Beer, Jean Paul Remon, Chris Vervaet – “Downstream processing from hot-melt extrusion towards tablets: a quality by design approach”, International Journal of Pharmaceutics 2017, 531, 235-245.
Glenn Verstraete, Lotte Vandenbussche, Sabah Kasmi, Lutz Nuhn, Davinia Brouckaert, Jeroen Van Renterghem, Wouter Grymonpré, Valérie Vanhoorne, Tom Coenye, Bruno G. De Geest, Thomas De Beer, Jean Paul Remon, Chris Vervaet – “Thermoplastic polyurethane-based intravaginal rings for prophylaxis and treatment of (recurrent) bacterial vaginosis”, International Journal of Pharmaceutics 2017, 529, 218-226.
Lien Lybaert, Nari Ryu, Lutz Nuhn, Riet De Rycke, Olivier De Wever, Alfred Chon, Aaron Esser-Kahn, Bruno G. De Geest – “Cancer Cell Lysate entrapment in CaCO3 Engineered with Polymeric TRL-agonists – Immunomodulating Microparticles in View of Personalized Anti-Tumor Vaccination”, Chemistry of Materials 2017, 29, 4209-4217.
Benoit Louage, Mies J. van Steenbergen, Lutz Nuhn, Martijn D. P. Risseeuw, Izet Karalic, Johan Winne, Serge Van Calenbergh, Wim E. Hennink, Bruno G. De Geest – “Micellar Paclitaxel-Initiated RAFT Polymer Conjugates with Acid-Sensitive Behavior”, ACS Macro Letters 2017, 6, 272-276.
Nane Vanparijs, Lutz Nuhn, Bruno G. De Geest – “Transiently Thermoresponsive Polymers and Their Application in Biomedicine“, Chemical Society Reviews 2017, 46, 1193-1239.
Nadine Leber, Leonard Kaps, Misbah Aslam, Jonathan Schupp, Alexander Brose, David Schäffel, Karl Fischer, Mustafa Diken, Dennis Strand, Kaloian Koynov, Andrea Tuettenberg, Lutz Nuhn,* Rudolf Zentel,* Detlef Schuppan* – “SiRNA-Mediated In Vivo Gene Knockdown by Acid-Degradable Cationic Nanohydrogel Particles“, Journal of Controlled Release 2017, 248, 10-23.
Zhiyue Zhang, Nane Vanparijs, Stef Vanhaaren, Filip E. Du Prez, Lutz Nuhn,* Bruno G. De Geest*– “Squaric Ester Amides as Hydrolysis-Resistant Functional Groups for Protein-Conjugation of RAFT Polymers“, Polymer Chemistry 2016, 7, 7242-7248.
Nane Vanparijs and Lutz Nuhn, Samantha J. Paluck, Maria Kokkinopoulou, Ingo Lieberwirth, Heather D. Maynard, Bruno G. De Geest – “Core/Shell Protein-Reactive Nanogels via a Combination of RAFT Polymerization and Vinyl Sulfone Postmodification“, Nanomedicine (Lond.) 2016, 11, 2631-2662.
Jörg Reichenwallner, Anja Thomas, Lutz Nuhn, Tobias Johann, Annette Meister, Holger Frey, Dariush Hinderberger – “Tunable Dynamic Hydrophobic Attachment of Guest Molecules in Amphiphilic Core-Shell Polymers“, Polymer Chemistry 2016, 7, 5783-5798 (Frontcover of Polymer Chemistry 2016, Vol. 7, Issue 37).
Benoit Louage, Lutz Nuhn, Martijn D. P. Risseeuw, Nane Vanparijs, Ruben De Coen, Izet Karalic, Serge Van Calenbergh, Bruno G. De Geest – “Well-Defined Polymer-Paclitaxel Prodrugs by a Grafting-from-Drug Approach”, Angewandte Chemie International Edition 2016, 55, 11791-11796; Angewandte Chemie 2016, 128, 11967-11973.
Lutz Nuhn,* Nane Vanparijs, Ans De Beuckelaer, Lien Lybaert, Glenn Verstraete, Kim Deswarte, Stephan Lienenklaus, Nikunj M. Shukla, Alex C. D. Salyer, Bart N. Lambrecht, Johan Grooten, Sunil A. David,* Stefaan De Koker,* Bruno G. De Geest* – “pH-Degradable Imidazoquinoline-Ligated Nanogels for Lymph Node Focused Immune Activation”, Proceedings of the National Academy of Sciences 2016, 113, 8098-8103.
Ruben De Coen, Nane Vanparijs, Martijn D. P. Risseeuw, Lien Lybaert, Benoit Louage, Stefaan De Koker, Vimal Kumar, Johan Grooten, Leeanne Taylor, Neil Ayres, Serge Van Calenbergh, Lutz Nuhn,* Bruno G. De Geest* – “pH-Degradable Mannosylated Nanogels for Dendritic Cell Targeting”, Biomacromolecules 2016, 17, 2479-2488 (Frontcover of Biomacromolecules 2016, Vol. 17, Issue 7).
Lutz Nuhn,* Leonard Kaps, Mustafa Diken, Detlef Schuppan, Rudolf Zentel* – “Reductive Decationizable Block Copolymers for Stimuli-Responsive mRNA Delivery”, Macromolecular Rapid Communications 2016, 37, 924-933.
Lien Lybaert, Nane Vanparijs, Kaat Fierens, Martijn Schuijs, Lutz Nuhn, Bart N. Lambrecht, Bruno G. De Geest – “A Generic Polymer-Protein Ligation Strategy for Vaccine Delivery”, Biomacromolecules 2016, 17, 874-881.
Zhyiue Zhang, Bert Schepens, Lutz Nuhn, Xavier Saelens, Michael Schotsaert, Nico Callewaert, Riet De Rycke, Qilu Zhang, Sébastien Moins, Samira Benali, Laetitia Mespouille, Richard Hoogenboom, Bruno G. De Geest– “Influenza-Binding Sialylated Polymer Coated Gold Nanoparticles Prepared via RAFT Polymerization and Reductive Amination“, Chemical Communications 2016, 52, 3352-3355.
Sabah Kasmi, Benoit Louage, Lutz Nuhn, Alexandra Van Driessche, Jan Van Deun, Izet Karalic, Martijn Risseeuw, Serge Van Calenbergh, Richard Hoogenboom, Riet De Rycke, Oliver De Wever, Wim E. Hennink, Bruno G. De Geest – “Transiently Responsive Block Copolymer Micelles Based on N-(2-Hydroxypropyl)methacrylamide Engineered with Hydrolyzable Ethylcarbonate Side Chains”, Biomacromolecules 2016, 17, 119-127.
Leonard Kaps and Lutz Nuhn, Mishah Aslam, Alexander Brose, Friedrich Foerster, Sebastian Rosigkeit, Patricia Renz, Rosario Heck, Yong Ook Kim, Ingo Lieberwirth, Detlef Schuppan, Rudolf Zentel – “In Vivo Gene-Silencing in Fibrotic Liver by siRNA-Loaded Cationic Nanohydrogel Particles”, Advanced Healthcare Materials 2015, 4, 2809-2815 (Frontcover of Advanced Healthcare Materials 2015, Vol. 4, Issue 18).
Elise Lepeltier and Lutz Nuhn, Claus-Michael Lehr, Rudolf Zentel – “Not Just for Tumor Targeting: Unmet Medical Needs and Opportunities for Nanomedicines”, Nanomedicine (Lond.) 2015, 10, 3147-3166.
Lutz Nuhn* – “Enhancing Gene Knockdown Efficiencies by Comparing siRNA-Loaded Cationic Nanogel Particles of Different Sizes”, RNA&Disease 2015, 2, e469.
Bettina Krieg, Markus Hirsch, Erik Scholz, Lutz Nuhn, Ilja Tabujew, Heiko Bauer, Sandra Decker, Andriy Khobta, Manfred Schmidt, Wolfgang Tremel, Rudolf Zentel, Kalina Peneva, Kaloian Koynov, A. James Mason, Mark Helm – „New Techniques to assess in vitro release of siRNA from nanoscale polyplexes”, Pharmaceutical Research 2015, 32, 1957-1974.
Sebastian Hartmann and Lutz Nuhn, Björn Palitzsch, Markus Glaffig, Natascha Stergiou, Bastian Gerlitzki, Edgar Schmitt, Rudolf Zentel, Horst Kunz – “CpG-Loaded Multifunctional Cationic Nanohydrogel Particles as Self-Adjuvanting Glycopeptide Antitumor Vaccines”, Advanced Healthcare Materials 2015, 4, 522-527.
Lutz Nuhn, Lydia Braun, Iris Overhoff, Annette Kelsch, David Schaeffel, Kaloian Koynov, Rudolf Zentel – “Degradable Cationic Nanohydrogel Particles for Stimuli-Responsive Release of siRNA”, Macromolecular Rapid Communications 2014, 35, 2057-2064 (Backcover of Macromolecular Rapid Communications 2014, Vol. 35, Issue 24).
Lutz Nuhn, Stephanie Tomcin, Kanjiro Miyata, Volker Mailänder, Katharina Landfester, Kazunori Kataoka, Rudolf Zentel – “Size-Dependent Knockdown Potential of siRNA-Loaded Cationic Nanohydrogel Particles”, Biomacromolecules 2014, 15, 4111-4121.
Lutz Nuhn* – “Addressing Dendritic Cells for Anticancer Immunity”, Journal of Antibody Drug Conjugates 2014, DOI:10.14229/jadc.2014.8.15.002.
Lutz Nuhn, Sabine Gietzen, Kristin Mohr, Karl Fischer, Kazuko Toh, Kanjiro Miyata, Yu Matsumoto, Kazunori Kataoka, Manfred Schmidt, Rudolf Zentel – “Aggregation Behavior of Cationic Nanohydrogel Particles in Human Blood Serum”, Biomacromolecules 2014, 15, 1526-1533.
Lutz Nuhn, Matthias Barz, Rudolf Zentel – “New Perspectives of HPMA-based Co-polymers Derived by Post-Polymerization Modification”, Macromolecular Bioscience 2014, 14, 607-618 (Backcover of Macromolecular Bioscience 2014 Vol. 14, Issue 5).
Markus Glaffig, Bjö̧rn Palitzsch, Sebastian Hartmann, Christoph Schüll, Lutz Nuhn, Bastian Gerlitzki, Edgar Schmitt, Holger Frey, Horst Kunz – “A Fully Synthetic Glycopeptide Antitumor Vaccine Based on Multiple Antigen Presentation on a Hyperbranched Polymer”, Chemistry – A European Journal 2014, 20, 4232-4236.
Lutz Nuhn,* Iris Overhoff, Marcel Sperner, Katrin Kaltenberg, Rudolf Zentel* – “RAFT-Polymerized Poly(hexafluoroisopropyl methacrylate)s as Precursor for Functional Water-Soluble Polymers”, Polymer Chemistry 2014, 5, 2484-2495.
Christian Moers, Lutz Nuhn, Marcel Wissel, Rene Stangenberg, Mihail Mondeshki, Elena Berger-Nicoletti, Anja Thomas, David Schaeffel, Kaloian Koynov, Markus Klapper, Rudolf Zentel, Holger Frey – “Supramolecular Linear-g-hyperbranched Graft Polymers: Topology and Binding Strength of Hyperbranched Side-Chains”, Macromolecules 2013, 46, 9544-5953.
Lutz Nuhn and Sebastian Hartmann, Björn Palitzsch, Bastian Gerlitzki, Edgar Schmitt, Rudolf Zentel, Horst Kunz – “Water-Soluble Polymers Coupled with Glycopeptide Antigens and T-Cell Epitopes as Potential Antitumor Vaccines”, Angewandte Chemie International Edition 2013, 52, 10652-10656; Angewandte Chemie 2013, 125, 10846-10850.
Lutz Nuhn, Christoph Schüll, Holger Frey, Rudolf Zentel – “Combining Ring-Opening Multibranching and RAFT Polymerization: Multifunctional Linear-Hyperbranched Block Copolymers via Hyperbranched Macro Chain Transfer Agents”, Macromolecules 2013, 46, 2892-2904.
Christoph Schüll, Lutz Nuhn, Christine Mangold, Eva Christ, Rudolf Zentel, Holger Frey – “Linear-Hyperbranched Graft-Copolymers via Grafting-to Strategy based on Hyperbranched Dendron Analogues and Reactive Ester Polymers”, Macromolecules 2012, 45, 5901-5910.
Lutz Nuhn, Markus Hirsch, Bettina Krieg, Kaloian Koynov, Karl Fischer, Manfred Schmidt, Mark Helm, Rudolf Zentel – Cationic Nanohydrogel Particles as Potential siRNA Carriers for Cellular Delivery”, ACS Nano 2012, 6, 2198-2214.
Daniel J Siegwart, Kathryn A Whitehead, Lutz Nuhn, Gaurav Sahay, Hao Cheng, Shan Jiang, Minglin Ma, Abigail Lytton-Jean, Arturo Vegas, Patrick Fenton, Christopher G Levins, Kevin T Love, Haeshin Lee, Christina Cortez, Sean P Collins, Ying Fei Li, Janice Jang, William Querbes, Christopher Zurenko, Tatiana Novobrantseva, Robert Langer, Daniel G Anderson – “Combinatorial Synthesis of Chemically Diverse Core-Shell Nanoparticles for Intracellular Delivery”, Proceedings of the National Academy of Sciences 2011, 108, 12996-13001.
