Research Topics
The current research projects in the Höbartner group address the following scientific topics:
- Chemical biology of natural RNA modifications: detection and quantitative analysis, design and synthesis of spectroscopic and mechanistic probes
- Functional nucleic acids: in vitro evolution of ribozymes, deoxyribozymes and aptamers with small molecule cofactors, fluorogenic RNA aptamers, methyltransferase ribozymes
- Expanding the scope of DNA/RNA-catalyzed reactions for RNA labelling and visualization
- Structures of DNA and RNA enzymes, mechanisms of nucleic acid catalysis
- Supramolecular chemistry with nucleic acid building blocks
- Modified nucleotides and oligonucleotides with therapeutic potential