-2013

E. Memmel, J. Seibel
Zuckersüß und richtig wichtig.
Nachrichten aus der Chemie 2013, 61, 1207–1211.

M. Timm, J. Görl, M. Kraus, S. Kralj, H. Hellmuth, R. Beine, K. Buchholz, L. Dijkhuizen, J. Seibel
An unconventional glycosyl transfer reaction: glucansucrase GTFA functions as an allosyltransferase enzyme.
ChemBioChem 2013, 14, 2423–2436.

E. Memmel, A. Homann, T. A. Oelschlaeger, J. Seibel
Metabolic glycoengineering of Staphylococcus aureus reduces its adherence to human T24 bladder carcinoma cells.
Chem. Commun. 2013, 49, 7301–7303.

J. Seibel, S. König, M. Sauer
Investigating infection processes with a workflow from organic chemistry to biophysics: The combination of metabolic glycoengineering, super-resolution fluorescence imaging and proteomics.
Expert Review of Proteomics, 2013, 10, 25–31. 

J. Seibel
From Gene to Product: Tailor-Made Oligosaccharides and Polysaccharides by Enzyme and Substrate Engineering.
in Carbohydrate-Modifying Biocatalysts
by Peter Grunwald (Ed.) Pan Stanford Publishing Pte. Ltd., Singapure (2012), 535–548.

A. Homann, M. Timm, J. Seibel
Chemo-enzymatic synthesis and in vitro cytokine profiling of tailor-made oligofructosides.
BMC Biotechnol. 2012, 12(1), 90.

J. Görl, M. Timm, J. Seibel
Mechanism-Oriented Redesign of an Isomaltulose Synthase to an Isomelezitose Synthase by Site-Directed Mutagenesis.
ChemBioChem 2012, 13, 149–156.

A. Goehler, N. Bertleff, M. Timm, S. Doose, J. Seibel, M. Sauer
Super-Resolution dSTORM Imaging of Human Galectin-1 Interacting with Neuroblastoma Cells.
Biophysical Journal 2012, 102, 223.

M. Ortiz-Soto, J. Seibel
Tailoring Enzymatic Reactions.
In Proceedings of the International Beilstein Symposium on Glyco-Bioinformatics
2nd International Beilstein Symposium on Glyco-Bioinformatics
Cracking the Sugar Code by Navigating the Glycospace 2012, 39–54.

M. Eppinger, B. Bunk, M. A. Johns, J. N. Edirisinghe, K. K. Kutumbaka, S. S. Koenig, H. H. Creasy, M. J. Rosovitz, D. R. Riley, S. Daugherty, M. Martin, L. D. Elbourne, I. Paulsen, R. Biedendieck, C. Braun, S. Grayburn, S. Dhingra, V. Lukyanchuk, B. Ball, R. Ul-Qamar, J. Seibel, E. Bremer, D. Jahn, J. Ravel, P. S. Vary
Genome sequences of the biotechnologically important Bacillus megaterium strains QM B1551 and DSM319.
J Bacteriol. 2011, 193, 199–213.

C. P. Strube, A. Homann, M. Gamer, D. Jahn, J. Seibel*, D.W. Heinz
Polysaccharide synthesis of the levansucrase SacB from Bacillus megaterium is controlled by distinct surface motifs.
J. Biol. Chem. 2011, 286, 17593–17600.

L. Hillringhaus, J. Seibel
Cracking the Glycocode: Recent Developments in Glycomics.
in Ideas in Chemistry and Molecular Sciences: Where Chemistry Meets Life (ed B. Pignataro),
Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2010.

L. Hillringhaus, J. Seibel*
Glycochips.
in "Encyclopedia of Industrial Biotechnology" (Flickinger, M. C., Ed.) Wiley, 2010.

K. Buchholz, J. Seibel*
Industrial applications of carbohydrates.
in "Encyclopedia of Industrial Biotechnology" (Flickinger, M. C., Ed.) Wiley, 2010.

J. Seibel*, H. J. Jördening, K. Buchholz
Extending Synthetic Routes for Oligosaccharides by Enzyme, Substrate and Reaction Engineering.
Adv Biochem Eng Biotechnol. 2010, 120, 163–193.

J. Seibel, K. Buchholz
Tools in Oligosaccharide Synthesis: Current Research and Application.
Advances in Carbohydrate Chemistry and Biochemistry, 2010, 63, 101–138.

A. Homann, R. ul-Qamar, S. Serim, P. Dersch, J. Seibel
Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid.
Beilstein J. Org. Chem. 2010, 6, 1–7.

A. Homann, J. Seibel
Chemo-enzymatic synthesis and functional analysis of natural and modified glycostructures.
Nat. Prod. Rep. 2009, 26, 1555–1571.

A. Homann, J. Seibel
Towards tailor-made oligosaccharides-chemo-enzymatic approaches by enzyme and substrate engineering.
Appl Microbiol Biotechnol. 2009, 83, 209–216.

R. Beine, A. Rocas Valente, R. Biedendieck, D. Jahn, J. Seibel
Directed optimization of biocatalytic transglycosylation processes by the integration of genetic algorithms and fermentative approaches into a kinetic model.
Process Biochemistry 2009, 44, 1103–1114.

J. Seibel, L. Hillringhaus
Glycochips - Dem Zuckercode auf der Spur.
Labor&more 5/2008

S. Kralj, K. Buchholz, L. Dijkhuizen, J. Seibel
Fructansucrase enzymes and sucrose analogues: new approach for the synthesis of unique fructo-oligosaccharides.
Biocatal. Biotrans 2008, 26, 32–42.

R. Beine, R. Moraru, M. Nimtz, S. Na'amnieh, A. Pawlowski, K. Buchholz, J. Seibel
Synthesis of novel fructooligosaccharides by substrate and enzyme engineering.
J. Biotechnol. 2008, 138, 33–41.

K. Buchholz, J. Seibel
Industrial carbohydrate biotransformations.
Carbohyr. Res. 2008, 343(12), 1966–79.

H. Hellmuth, S. Wittrock, S. Kralj, L. Dijkhuizen, B. Hofer, J. Seibel
Engineering the Glucansucrase GTFR enzyme reaction- and glycosidic bond specificity: towards tailor-made polymer and oligosaccharide products.
Biochemistry 2008, 47, 6678–6684.

A. Zuccaro, S. Götze, S. Kneip, P. Dersch, J. Seibel
Taylor made fructooligosaccharides by combination of substrate and genetic engineering.
ChemBioChem 2008, 9, 143–149.

R. Biedendieck, R. Beine, M. Gamer, E. Jordan, K. Buchholz, J. Seibel, L. Dijkhuizen, M. Malten, D. Jahn
Export, purification and activities of affinity tagged Lactobacillus reuteri levansucrase produced by Bacillus megaterium.
Appl Microbiol Biotechnol 2007, 74(5), 1062–1073.

A. Homann, R. Biedendieck, S. Götze, D. Jahn, J. Seibel
Insights into polymer versus oligosaccharide synthesis - mutagenesis and mechanistic studies of a novel levansucrase from Bacillus megaterium.
Biochem J. 2007, 407, 189–198.

H. Hellmuth, L. Hillringhaus, S. Höbbel, S. Kralj, L. Dijkhuizen, J. Seibel
Highly efficient Chemoenzymatic Synthesis of Novel branched Thiooligosaccharides via Substrate Direction using Glucansucrases.
ChemBioChem 2007, 8, 273–276.

J. Seibel, H.-J. Jördening, K. Buchholz
Glycosylation with activated sugars using glycosyltransferases and transglycosidases.
Biocat. Biotrans. 2006, 24, 311–354.

J. Seibel, H. Hellmuth, B. Hofer, B. Schmalbruch
Identification of new donor specificities of Glycosyltransferase R via the aid of substrate microarrays.
ChemBioChem 2006, 7, 310–320.

W. Pohl, H. Hellmuth, M. Hilbert, J. Seibel, P. J. Walla
A two-photon fluorescence correlation study of lectins interacting with carbohydrated 20 nm beads.
ChemBioChem 2006, 7, 268–274.

J. Seibel, R. Moraru, S. Götze, S. Na'amnieh, A. Pawlowski, K. Buchholz
Synthesis of sucrose analogues and the mechanism of action of Bacillus subtilis fructosyltransferase (levansucrase).
Carbohydr. Res. 2006, 341, 2335–2349.

J. Seibel, R. Beine, R. Moraru, C. Behringer, K. Buchholz
A New Pathway for the Synthesis of Oligosaccharides by the Use of non-Leloir glycosyltransferases.
Biocat. Biotrans. 2006, 24, 157–165.

J. Seibel
Enzymatische Oligosaccharidsynthesen: vom Gen zum Produkt.
Nachrichten aus der Chemie 2006, 2, 110–114.

J. Seibel
Biocatalysis.
by A. S. Bommarius and B. R. Riebel.
Chemie Ingenieur Technik (2005), 77(3), 311–312.

I. E. Baciu, H. J. Jördening, J. Seibel, K. Buchholz
Investigations of the transfructosylation reaction by fructosyltransferase from B. subtilis NCIMB 11871 for the synthesis of the sucrose analogue galactosyl-fructoside.
J. Biotechnol. 2005, 116, 347–357.

J. Seibel, S. J. Macdonald, C. J. Schofield
Synthesis of δ-lactam (2-oxopiperazine) inhibitors of elastase.
Journal Chemical Research 2005, 12, 826–832.

J. Seibel, R. Moraru, S. Götze
Biocatalytic and chemical investigations in the synthesis of sucrose analogues.
Tetrahedron 2005, 61, 7081–7086.

J. Seibel, L. Hillringhaus, R. Moraru
Microwave-assisted Glycosylation for the Synthesis of Glycopeptides.
Carbohydr. Res. 2005, 340, 507–511.

K. Buchholz, J. Seibel
Isomaltooligosaccharides.
in Oligosaccharides in Food and Agriculture
Edited by Gillian Eggleston and Gregory L. Coté
ACS Publication, Oxford University Press, 2003, Washington

J. Seibel*, K. Buchholz
Chemoenzymatische Synthese von Oligosacchariden und glykosylierten Naturstoffen.
Transkript (Sonderheft Nachhaltige Biokatalyse) 2003, 9, 40–41.

J. Seibel, D. Brown, A. Amour, S. J. Macdonald, N. J. Oldham, C. J. Schofield
Synthesis and evaluation of delta-Lactams (Piperazones) as elastase inhibitors.
Bioorg Med Chem Lett. 2003, 13, 387–389.

J. J. Turnbull, M. J. Nagle, J. Seibel, R. W. Welford, G. H. Grant, C. J. Schofield
The C-4 stereochemistry of leucocyanidin substrates for anthocyanidin synthase affects product selectivity.
Bioorg Med Chem Lett. 2003, 13, 3853–3857.

J. M. Elkins, K. S. Hewitson, L. A. McNeill, J. F. Seibel, I. Schlemminger, C. W. Pugh, P. J. Ratcliffe, C. J. Schofield
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
J. Biol. Chem. 2003, 278, 1802–1806.

L. A. McNeill, K. S. Hewitson, T. D. Claridge, J. F. Seibel, L. E. Horsfall, C. J. Schofield
Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.
Biochem. J. 2002, 367, 571–575.

L. F. Tietze, J. Seibel, F. Djalali Bazzaz, J. Görlitzer, J. H. Peters
Monoclonal Antibody against Vitamin E.
Immunobiology 1999, 200, 713.

Encyclopedia

ROEMPP Online, section carbohydrates

Patents

Method for synthesizing oligosaccharides and glycosylation.
J. Seibel, H.-J. Jördening, K. Buchholz, R. Beine
PCT/EP 2006/060932 (2006)

Method for selecting catalytic antibodies.
L. F. Tietze, J. Seibel, F. Djalali Bazzaz, J. H. Peters
WO0028330.

Catalytic antibodies and method for producing chromanes by cyclization with said antibodies.
L. F. Tietze, J. Seibel, F. Djalali Bazzaz, J. H. Peters
WO0028063.

Antibodies, mini-antibodies or antibody fragments binding to vitamin E and the use thereof.
L. F. Tietze, J. Seibel, F. Djalali Bazzaz, J. H. Peters
WO0027884.