Prof. Dr. C. Höbartner

Prof. Dr. Claudia Höbartner

Universität Würzburg
Institut für Organische Chemie and
Center for Nanosystems Chemistry
Am Hubland
97074 Würzburg

Phone: +49 931 31-89693
Fax: +49 931 31-84755
claudia.hoebartner@uni-wuerzburg.de

Chair Coordination

Eleonore Klaus

Phone: +49 931 31-85322
l-oc1.chemie@uni-wuerzburg.de
eleonore.klaus@uni-wuerzburg.de

Welcome

Explore with us the exciting chemistry of nucleic acids! We synthesize chemically modified DNA and RNA, develop DNA catalysts, ribozymes and RNA aptamers, and explore their functions and innovative applications at the interface of chemistry and biology.

Just Published

I. Bessi, C. Stiller, T. Schroeder, B. Schäd, M. Grüne, J. Dietzsch, C. Höbartner, The Tautomeric State of N⁴-Hydroxycytidine within Base-Paired RNA, ACS Cent. Sci. 2024, published online April 25, 2024

C. Höbartner, K.E. Bohnsack, M.T. Bohnsack. How Natural Enzymes and Synthetic Ribozymes Generate Methylated Nucleotides in RNA. Annu Rev Biochem. 2024 Apr 10.

F. Seitz, T. Jungnickel, N. Kleiber, J. Kretschmer, J. Adelmann, J. Dietzsch, K.E. Bohnsack, M.T. Bohnsack, C. Höbartner. Atomic mutagenesis of N⁶-methyladenosine reveals distinct recognition modes of human m⁶A reader and eraser proteins J. Am. Chem. Soc. 2024, published online March 6

M. Müller, H. Neitz, C. Höbartner, H. Helten, BN-Phenanthrene- and BN-Pyrene-Based Fluorescent Uridine Analogues. Org. Lett. 2024, Jan 29.

H. Neitz and C. Höbartner. A tolane-modified 5-ethynyluridine as a universal and fluorogenic photochemical DNA crosslinker. Chem Commun. 2023 Sep 20. doi: 10.1039/d3cc03796g.

T. Okuda, A.-K. Lenz, F. Seitz, J. Vogel, C. Höbartner. A SAM analogue-utilizing ribozyme for site-specific RNA alkylation in living cells, Nat. Chem. 2023, published online September 4, 2023

News

Award for outstanding PhD thesis

Congratulations Dr Carolin Scheitl for receiving the "Gemeinsamen Promotionspreis der Unterfränkischen Gedenkjahrstiftung für Wissenschaft und der Julius-Maximilians-Universität Würzburg"

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Congratulations Dr. Neitz!

On December 19th, 2023 Hermann Neitz successfully defended his PhD on "Hydrophobic recognition motifs in functionalized DNA". Many congratulations and all best wishes for a bright future!

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